Ochratoxin B-13C20 (OTB-13C20) is intended for use as an internal standard for the quantification of ochratoxin B by GC- or LC-MS. OTB is a mycotoxin that has been found in Aspergillus and is a non-chlorinated derivative of OTA .[1] Unlike OTA, OTB is not genotoxic to HepG2 cells but does inhibit cell division when used at concentrations ranging from 1 to 25 µg/ml.[2] It induces mortality (LC50 = 700 nM) and craniofacial malformations (EC50 = 200 nM) in Xenopus embryos.[3] OTB has been found in poultry feed.[4]
References:
[1].Varga, J., Kevei, E., Rinyu, E., et al.Ochratoxin production by Aspergillus speciesAppl. Environ. Microbiol.62(12)4461-4464(1996).
[2].Knasmüller, S., Cavin, C., Chakraborty, A., et al.Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessmentNutr. Cancer50(2)190-197(2004).
[3].O'Brien, E., Prietz, A., and Dietrich, D.R.Investigation of the teratogenic potential of ochratoxin A and B using the FETAX systemBirth Defects Res. B Dev. Reprod. Toxicol.74(5)417-423(2005).
[4].Ezekiel, C.N., Bandyopadhyay, R., Sulyok, M., et al.Fungal and bacterial metabolites in commercial poultry feed from NigeriaFood Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess.29(8)1288-1299(2012).