Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC4152917-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic AcidCAS: 1233715-28-0纯度: >90.00%
A metabolite of DHA with anti-inflammatory properties
- GC41552ω-3 Arachidonic AcidCAS: 24880-40-8纯度: >98.00%
A rare, natural 20:4 ω-3 polyunsaturated fatty acid
- GC41649(±)13-HODE cholesteryl esterCAS: 167354-91-8纯度: >98.00%
A 15-LO product derived from cholesteryl linoleate
- GC41661(±)-4-hydroxy Propranolol β-D-GlucuronideCAS: 94731-13-2纯度: >90.00%
A metabolite of propranolol
- GC41666(±)9-HODE cholesteryl esterCAS: 33783-76-5纯度: >98.00%
A racemic monohydroxy fatty acid cholesteryl ester
- GC41670(±)-Epinephrine (hydrochloride)CAS: 329-63-5纯度: >98.00%
(±)-Epinephrine (hydrochloride)是一种肾上腺素能受体激动剂，在低剂量时，主要激活β受体，增强支气管扩张和心脏活动；而在高剂量时，(±)-Epinephrine (hydrochloride)会与α受体结合，引起血管收缩并增加血管张力。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC41390 | Aldosterone | 52-39-1 | >98.00% / >95.00% | |
醛固酮是由肾上腺皮质分泌的一种类固醇激素，是控制钠和钾平衡的主要矿物质皮质激素 | ||||
| GC41399 | 5α-dihydro Levonorgestrel | 78088-19-4 | >95.00% | |
A metabolite of levonorgestrel | ||||
| GC41403 | 15(S)-HpEDE | 145375-41-3 | >98.00% | |
A 15-LO product derived from eicosadienoic acid | ||||
| GC41415 | 15(R)-Lipoxin A4 | 171030-11-8 | >95.00% | |
An aspirin-triggered lipoxin | ||||
| GC41421 | 20-hydroxy Leukotriene B4 | 79516-82-8 | >97.00% | |
A LTB 4 metabolite | ||||
| GC41424 | 6(S)-Lipoxin A4 | 94292-80-5 | >95.00% | |
An isomer of LXA 4 | ||||
| GC41477 | 3-Hydroxyglutaric Acid | 638-18-6 | >95.00% | |
A biomarker for GCDH deficiency | ||||
| GC41478 | L-α-Hydroxyglutaric Acid | 13095-48-2 | >95.00% | |
L-α-羟基戊二酸是生命各个领域的重要代谢产物。 | ||||
| GC41480 | 3'-hydroxy Lidocaine | 34604-55-2 | >98.00% | |
A metabolite of lidocaine | ||||
| GC41529 | 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid | 1233715-28-0 | >90.00% | |
A metabolite of DHA with anti-inflammatory properties | ||||
| GC41531 | Anacardic Acid Triene | 103904-73-0 | >98.00% | |
A polyunsaturated form of anacardic acid | ||||
| GC41532 | Benzisoxazole Hsp90 Inhibitor | 1012788-65-6 | >98.00% | |
Hsp90 chaperone inhibitor | ||||
| GC41552 | ω-3 Arachidonic Acid | 24880-40-8 | >98.00% | |
A rare, natural 20:4 ω-3 polyunsaturated fatty acid | ||||
| GC41565 | 3-hydroxy Medetomidine | 128366-50-7 | >95.00% | |
A metabolite of medetomidine | ||||
| GC41586 | cis-Petroselinic Acid | 593-39-5 | >98.00% | |
A monounsaturated fatty acid | ||||
| GC41638 | TSI-01 | 704878-75-1 | >95.00% / >98.00% | |
TSI-01是溶血磷脂酰胆碱酰基转移酶2（LPCAT2）的选择性抑制剂，对人 LPCAT2和LPCAT1的IC 50 值分别为0.47和3.02μM。 | ||||
| GC41642 | 9(E),11(E),13(E)-Octadecatrienoic Acid | 544-73-0 | >97.00% | |
A polyunsaturated fatty acid | ||||
| GC41649 | (±)13-HODE cholesteryl ester | 167354-91-8 | >98.00% | |
A 15-LO product derived from cholesteryl linoleate | ||||
| GC41661 | (±)-4-hydroxy Propranolol β-D-Glucuronide | 94731-13-2 | >90.00% | |
A metabolite of propranolol | ||||
| GC41666 | (±)9-HODE cholesteryl ester | 33783-76-5 | >98.00% | |
A racemic monohydroxy fatty acid cholesteryl ester | ||||
| GC41670 | (±)-Epinephrine (hydrochloride) | 329-63-5 | >98.00% | |
(±)-Epinephrine (hydrochloride)是一种肾上腺素能受体激动剂，在低剂量时，主要激活β受体，增强支气管扩张和心脏活动；而在高剂量时，(±)-Epinephrine (hydrochloride)会与α受体结合，引起血管收缩并增加血管张力。 | ||||
| GC41671 | (±)-Equol 4'-sulfate (sodium salt) | 1189685-28-6 | >90.00% | |
A metabolite of (±)-equol | ||||
| GC41694 | (3S)-hydroxy Quinidine | 53467-23-5 | >98.00% | |
An active quinidine metabolite | ||||
| GC41721 | (R)-α-Lipoic Acid | 1200-22-2 | >99.50% | |
A cyclic disulfide antioxidant | ||||