GlpBio

(±)-Epinephrine (hydrochloride)

目录号: GC41670纯度: >98.00%同义词: 肾上腺素盐酸盐
(±)-Epinephrine (hydrochloride)是一种肾上腺素能受体激动剂，在低剂量时，主要激活β受体，增强支气管扩张和心脏活动；而在高剂量时，(±)-Epinephrine (hydrochloride)会与α受体结合，引起血管收缩并增加血管张力。
(±)-Epinephrine (hydrochloride)
Cas No.: 329-63-5
规格价格库存数量操作
1g¥325.00现货
1
5g¥728.00现货
1
10g¥1,300.00现货
1
25g¥2,847.00现货
1
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产品描述 Description

(±)-Epinephrine (hydrochloride) is an adrenergic receptor agonist that, at low doses, primarily activates β receptors to enhance bronchodilation and cardiac activity, while at high doses (±)-Epinephrine (hydrochloride) binds to α receptors, inducing vasoconstriction and increasing vascular tension[1].

In vitro, (±)-Epinephrine (hydrochloride) (100μM; 4h) stimulates the secretion of phosphatidylcholine (PC) from type II cells of embryonic chickens at all stages[2]. (±)-Epinephrine (hydrochloride) (55-550μM; 3 days) inhibited the growth of trabecular meshwork cells in a dose-dependent manner[3].

In vivo, (±)-Epinephrine (hydrochloride) (1mg/kg/5μl; 0.5-60min) prolonged the localization of lidocaine applied to the mucosa and inhibited its absorption into the bloodstream of rats[4]. Low and medium doses of (±)-Epinephrine (hydrochloride) (0.04, 0.2 and 0.4mg/kg; 10min; i.v.) were more optimal for CPR in a rat asphyxial cardiac arrest model[5].

References:
[1] Dalal R, Grujic D. Epinephrine. 2024 Nov 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.
[2] Sullivan LC, Orgeig S. Dexamethasone and epinephrine stimulate surfactant secretion in type II cells of embryonic chickens. Am J Physiol Regul Integr Comp Physiol. 2001 Sep;281(3):R770-7.
[3] Kawa JE, Higginbotham EJ, Chang IL, et al. Effects of antiglaucoma medications on bovine trabecular meshwork cells in vitro. Exp Eye Res. 1993 Nov;57(5):557-65.
[4] Sasaki R, Sunada K. Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats. BMC Oral Health. 2021 Jul 1;21(1):327.
[5] Chen MH, Lu JY, Xie L, et al. What is the optimal dose of epinephrine during cardiopulmonary resuscitation in a rat model? Am J Emerg Med. 2010 Mar;28(3):284-90.

(±)-Epinephrine (hydrochloride)是一种肾上腺素能受体激动剂，在低剂量时，主要激活β受体，增强支气管扩张和心脏活动；而在高剂量时，(±)-Epinephrine (hydrochloride)会与α受体结合，引起血管收缩并增加血管张力[1]。

在体外实验中，(±)-Epinephrine (hydrochloride)（100μM; 4小时）可刺激胚胎鸡II型细胞在所有阶段分泌磷脂酰胆碱（PC）[2]。(±)-Epinephrine (hydrochloride)（55-550μM; 3天）以剂量依赖性方式抑制小梁网细胞的生长[3]。

在体内实验中，(±)-Epinephrine (hydrochloride)（1mg/kg/5μl; 0.5-60分钟）延长了应用于大鼠黏膜的利多卡因的定位时间，并抑制其吸收进入血液循环[4]。在大鼠窒息性心脏骤停模型中，低剂量和中等剂量的(±)-Epinephrine (hydrochloride)（0.04, 0.2和0.4mg/kg; 10分钟; 静脉注射）更适合心肺复苏（CPR）[5]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

bovine trabecular meshwork cells

Preparation Method

Forty thousand bovine trabecular meshwork cells were plated into each well of a 12-well Corning tissue culture plate. After 24h, growth medium containing (±)-Epinephrine (hydrochloride) (55-550μM) was added, and the cells were treated for 3 days. Cultures without drug treatment served as controls.

Reaction Conditions

55-550μM; 3 days

Applications

(±)-Epinephrine (hydrochloride) (55-550μM; 3 days) inhibited the growth of trabecular meshwork cells in a dose-dependent manner.
Animal experiment [2]:

Animal models

Sprague Dawley (SD) male rats

Preparation Method

Rat cardiac arrest was induced via asphyxia. Cardiac arrest was determined by the disappearance of arterial pulsations on intravascular pressure monitors, a mean aortic blood pressure of less than 10mmHg, and the presence of ventricular fibrillation, pulseless electrical activity, or asystole. The changes in cardiac arrest rhythm were observed and recorded at the end of asphyxia. The animals were prospectively randomized into 4 groups (n = 10/group): the saline group (treated with normal saline, 1mL i.v.), low-dose (±)-Epinephrine (hydrochloride) group (treated with (±)-Epinephrine (hydrochloride), 0.04mg/kg i.v.), medium-dose (±)-Epinephrine (hydrochloride) group (treated with epinephrine, 0.2mg/kg i.v.), or high-dose (±)-Epinephrine (hydrochloride) group (treated with (±)-Epinephrine (hydrochloride), 0.4mg/kg i.v.). At the end of 10min of asphyxia, the corresponding drugs were administered to each group in a blinded fashion, and then cardiopulmonary resuscitation (CPR) was initiated, with each drug being administered at the same time (the drug was given only once at this point in all groups). Ventilation was performed using a small animal ventilator, with a respiratory rate of 70 breaths per minute and a tidal volume adjusted to 6mL/kg. Chest compressions were performed using a pneumatically driven mechanical chest compressor developed by us. The compression rate was maintained at 180/min with equal compression-relaxation duration. The compression depth was about 30% of the anteroposterior chest diameter at maximal compression. This mechanical chest compressor ensured that chest compressions were the same for all animals. Return of spontaneous circulation was defined as the return of supraventricular rhythm with a mean arterial pressure (MAP) of 20mmHg or higher for a minimum of 5min. If spontaneous circulation was not restored within 10min, resuscitation efforts were discontinued.

Dosage form

0.04, 0.2 and 0.4mg/kg; 10min; i.v.

Applications

Low and medium doses of (±)-Epinephrine (hydrochloride) were more optimal for CPR in a rat asphyxial cardiac arrest mode.

References:
[1] Kawa JE, Higginbotham EJ, Chang IL, et al. Effects of antiglaucoma medications on bovine trabecular meshwork cells in vitro. Exp Eye Res. 1993 Nov;57(5):557-65.
[2] Chen MH, Lu JY, Xie L, et al. What is the optimal dose of epinephrine during cardiopulmonary resuscitation in a rat model? Am J Emerg Med. 2010 Mar;28(3):284-90.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
329-63-5
同义词
肾上腺素盐酸盐
SMILES
OC1=C(O)C=CC(C(O)CNC)=C1.Cl
分子式
C9H13NO3•HCl
分子量
219.7 g/mol
溶解性
DMF: 20 mg/ml,DMSO: 20 mg/ml,PBS (pH 7.2): 5 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

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