Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC408305,6-dehydro Arachidonic AcidCAS: 58688-54-3纯度: >98.00%
An analog of arachidonic acid with acetylene in the 5,6 position
- GC408794-hydroxy Solifenacin N-oxideCAS: 2747991-39-3纯度: >95.00%
An N-oxide form of 4-hydroxy solifenacin
- GC409268-Hydroxy-2'-deoxyguanosineCAS: 88847-89-6纯度: >98.00% / >96.00%
8-Hydroxy-2'-deoxyguanosine是氧化应激诱导的DNA损伤的关键生物标志物，用于评估多种癌症和退行性疾病的风险。
- GC40928Trimethylamine N-oxideCAS: 1184-78-7纯度: >95.00%
A metabolite of choline, phosphatidylcholine, and L-carnitine
- GC4097110(S),17(S)-DiHDHACAS: 871826-47-0纯度: >98.00%
A DHA derivative with anti-inflammatory and anti-platelet activity
- GC40982Resolvin D5CAS: 578008-43-2纯度: >95.00%
A potent anti-inflammatory, pro-resolving lipid mediator
- GC410034'-O-methyl QuercetinCAS: 603-61-2纯度: >98.50%
A flavonoid with anticancer and antiplasmodial activity
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC40830 | 5,6-dehydro Arachidonic Acid | 58688-54-3 | >98.00% | |
An analog of arachidonic acid with acetylene in the 5,6 position | ||||
| GC40834 | cis-Entacapone | 145195-63-7 | >98.00% | |
A metabolite of entacapone | ||||
| GC40839 | 15(S)-HETE methyl ester | 70946-44-0 | >98.00% | |
A synthetic derivative of 15(S)-HETE | ||||
| GC40840 | Leukotriene A3 methyl ester | 83851-38-1 | >97.00% | |
A metabolically stable form of LTA 3 | ||||
| GC40852 | N-Demethylerythromycin A | 992-62-1 | >95.00% | |
A metabolite of erythromycin | ||||
| GC40879 | 4-hydroxy Solifenacin N-oxide | 2747991-39-3 | >95.00% | |
An N-oxide form of 4-hydroxy solifenacin | ||||
| GC40913 | Glycohyodeoxycholic Acid | 13042-33-6 | >98.00% | |
A metabolite of hyodeoxycholic acid | ||||
| GC40926 | 8-Hydroxy-2'-deoxyguanosine | 88847-89-6 | >98.00% / >96.00% | |
8-Hydroxy-2'-deoxyguanosine是氧化应激诱导的DNA损伤的关键生物标志物，用于评估多种癌症和退行性疾病的风险。 | ||||
| GC40928 | Trimethylamine N-oxide | 1184-78-7 | >95.00% | |
A metabolite of choline, phosphatidylcholine, and L-carnitine | ||||
| GC40968 | 21-hydroxy Eplerenone | 334678-67-0 | >98.00% | |
A major metabolite of eplerenone | ||||
| GC40971 | 10(S),17(S)-DiHDHA | 871826-47-0 | >98.00% | |
A DHA derivative with anti-inflammatory and anti-platelet activity | ||||
| GC40975 | 17(S)-HpDHA | 123673-33-6 | >98.00% | |
A mono-oxygenation product of DHA | ||||
| GC40978 | 7-epi Maresin 1 | 1268720-66-6 | >95.00% | |
An inactive Maresin 1 epimer | ||||
| GC40980 | Maresin 2 | 1639809-46-3 | ≥95.00% | |
A 13R,14S-dihydroxy DHA produced by macrophages | ||||
| GC40981 | Protectin D1 | 660430-03-5 | >98.00% | |
A specialized pro-resolving mediator | ||||
| GC40982 | Resolvin D5 | 578008-43-2 | >95.00% | |
A potent anti-inflammatory, pro-resolving lipid mediator | ||||
| GC40994 | N-Methylnicotinamide | 114-33-0 | >98.00% | |
An isomer of nicotinamide | ||||
| GC40998 | Pinostrobin | 480-37-5 | >98.00% / >99.50% | |
Pinostrobin是一种天然类黄酮，具有抗氧化、抗炎、抗病毒和抗癌等多种生物活性。 | ||||
| GC41003 | 4'-O-methyl Quercetin | 603-61-2 | >98.50% | |
A flavonoid with anticancer and antiplasmodial activity | ||||
| GC41044 | CAY10583 | 862891-27-8 | >98.00% | |
A selective BLT 2 agonist | ||||
| GC41095 | 12(S)-HpEPE | 103239-14-1 | >96.00% | |
A 12-LO product derived from EPA | ||||
| GC41096 | 12-oxo Leukotriene B4 | 136696-10-1 | >90.00% | |
A natural metabolite of LTB 4 | ||||
| GC41100 | 14,15-dehydro Leukotriene B4 | 114616-11-4 | >97.00% | |
A LTB 4 receptor antagonist | ||||
| GC41101 | 15(S)-HpEPE | 125992-60-1 | >98.00% | |
Produced by the action of 15-lipoxygenase on EPA | ||||