Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC4112312-epi Leukotriene B4CAS: 83709-73-3纯度: >97.00%
LTB 4 isomer with weak agonist activity at BLT 1 and BLT 2 receptors
- GC411275(S),15(S)-DiHETECAS: 82200-87-1纯度: >98.00%
A dihydroxy fatty acid synthesized by 15-LO from 5(S)-HETE
- GC411368(S),15(S)-DiHETECAS: 80234-65-7纯度: >98.00%
A dihydroxy fatty acid synthesized by 15-LO from 15(S)-HETE
- GC4115014,15-Leukotriene E4CAS: 1000852-57-2纯度: >97.00%
A metabolite of 14,15-LTC 4 with pro-inflammatory activity
- GC41151Decursinol angelateCAS: 130848-06-5纯度: >98.00%
Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.
- GC4120917-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic AcidCAS: 1233715-33-7
A metabolite of DPA with anti-inflammatory properties
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC41105 | 5(S)-HpEPE | 143292-98-2 | >95.00% | |
Produced by the action of 5-LO on EPA; LTA 5 precursor | ||||
| GC41107 | Leukotriene B5 | 80445-66-5 | >98.00% | |
A leukotriene | ||||
| GC41122 | 12(S)-HpETE | 71774-10-2 | >98.00% | |
A 12-LO metabolite of arachidonic acid | ||||
| GC41123 | 12-epi Leukotriene B4 | 83709-73-3 | >97.00% | |
LTB 4 isomer with weak agonist activity at BLT 1 and BLT 2 receptors | ||||
| GC41124 | 15(S)-HpETE | 70981-96-3 | >95.00% | |
A product of 15-LO metabolism of arachidonic acid | ||||
| GC41126 | 5(S),12(S)-DiHETE | 79056-01-2 | >98.00% | |
A natural bioactive lipid | ||||
| GC41127 | 5(S),15(S)-DiHETE | 82200-87-1 | >98.00% | |
A dihydroxy fatty acid synthesized by 15-LO from 5(S)-HETE | ||||
| GC41128 | 5(S),6(R)-11-trans DiHETE | 129263-59-8 | >95.00% | |
A metabolite of LTA 4 | ||||
| GC41136 | 8(S),15(S)-DiHETE | 80234-65-7 | >98.00% | |
A dihydroxy fatty acid synthesized by 15-LO from 15(S)-HETE | ||||
| GC41144 | 11-trans Leukotriene C4 | 74841-69-3 | >97.00% | |
A C-11 double bond isomer of LTC 4 | ||||
| GC41145 | 14,15-Leukotriene C4 | 75290-60-7 | >95.00% | |
A pro-inflammatory arachidonic acid metabolite | ||||
| GC41147 | 11-trans Leukotriene D4 | 79768-40-4 | >97.00% | |
A C-11 double bond isomer of LTD 4 | ||||
| GC41148 | 14,15-Leukotriene D4 | 75290-64-1 | >97.00% | |
A pro-inflammatory arachidonic acid metabolite | ||||
| GC41149 | 11-trans Leukotriene E4 | 75715-88-7 | >97.00% | |
The C-11 double bond isomer of LTE 4 | ||||
| GC41150 | 14,15-Leukotriene E4 | 1000852-57-2 | >97.00% | |
A metabolite of 14,15-LTC 4 with pro-inflammatory activity | ||||
| GC41151 | Decursinol angelate | 130848-06-5 | >98.00% | |
Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A. | ||||
| GC41177 | Lurasidone metabolite 14283 | 186204-31-9 | >95.00% | |
An active metabolite of lurasidone | ||||
| GC41183 | α-Carotene | 7488-99-5 | >95.00% | |
A precursor of vitamin A | ||||
| GC41189 | Ricinelaidic Acid | 540-12-5 | >98.00% | |
An LTB 4 antagonist | ||||
| GC41206 | 14(S)-HDHA | 119433-37-3 | >98.00% | |
An anti-inflammatory lipid produced by macrophages | ||||
| GC41208 | 17(S)-HDHA | 92693-03-3 | >98.00% | |
An oxidation product of DHA | ||||
| GC41209 | 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid | 1233715-33-7 | - | |
A metabolite of DPA with anti-inflammatory properties | ||||
| GC41211 | Anacardic Acid Diene | 103904-74-1 | >95.00% | |
A polyunsaturated for of anacardic acid | ||||
| GC41220 | 13(S)-HODE methyl ester | 109837-85-6 | >98.00% | |
Hydroxy fatty acid methyl ester | ||||