Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC484402'-Deoxycytidine-5'-triphosphate (sodium salt)CAS: 109909-44-6纯度: >95.00%
A nucleoside triphosphate
- GC48509Apigenin 7-O-Glucuronide (hydrate)纯度: >95.00%
Apigenin 7-O-glucuronide is a flavonoid that has been found in J
- GC48528Piericidin BCAS: 16891-54-6纯度: >98.00%
A bacterial metabolite with insecticidal and antimicrobial activities
- GC48611Ambroxol-d5CAS: 1246818-80-3纯度: >99.00%
An internal standard for the quantification of ambroxol
- GC486497-hydroxy Chlorpromazine (hydrochloride)CAS: 51938-11-5纯度: >98.00%
An active metabolite of chlorpromazine
- GC48659UmbellipreninCAS: 532-16-1; 23838-17-7纯度: >98.00%
A prenylated coumarin with diverse biological activities
- GC48738(±)12-HETE-d8CAS: 2525175-25-9纯度: >99.00%
An internal standard for the quantification of 12-HETE
- GC48739(±)15-HETE-d8CAS: 2525175-31-7纯度: >99.00%
An internal standard for the quantification of 15-HETE
- GC48850Carbazomycin CCAS: 108073-62-7纯度: >95.00%
A bacterial metabolite with diverse biological activities
- GC48893Carbazomycin BCAS: 75139-38-7纯度: >95.00%
A bacterial metabolite with diverse biological activities
- GC48948α-Ketoglutaric Acid (sodium salt)CAS: 22202-68-2纯度: >98.00%
An intermediate in the citric acid cycle
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC48430 | Ac-DEVD-CMK (trifluoroacetate salt) | - | >98.00% | |
An inhibitor of caspase-3 | ||||
| GC48440 | 2'-Deoxycytidine-5'-triphosphate (sodium salt) | 109909-44-6 | >95.00% | |
A nucleoside triphosphate | ||||
| GC48457 | 3-keto Fusidic Acid | 4680-37-9 | >95.00% | |
An active metabolite of fusidic acid | ||||
| GC48461 | rac-trans-4-hydroxy Glyburide | 23155-00-2 | >98.00% | |
An active metabolite of glyburide | ||||
| GC48464 | GC376 (sodium salt) | 1416992-39-6 | >98.00% | |
An inhibitor of 3C- and 3C-like proteases | ||||
| GC48493 | PCI 45227 | 1654820-87-7 | >99.50% | |
An active metabolite of ibrutinib | ||||
| GC48509 | Apigenin 7-O-Glucuronide (hydrate) | - | >95.00% | |
Apigenin 7-O-glucuronide is a flavonoid that has been found in J | ||||
| GC48526 | MXS | - | >90.00% | |
A fluorescent probe for hypochlorous acid | ||||
| GC48528 | Piericidin B | 16891-54-6 | >98.00% | |
A bacterial metabolite with insecticidal and antimicrobial activities | ||||
| GC48547 | Sartorypyrone D | 1801167-48-5 | >95.00% | |
A fungal metabolite | ||||
| GC48611 | Ambroxol-d5 | 1246818-80-3 | >99.00% | |
An internal standard for the quantification of ambroxol | ||||
| GC48649 | 7-hydroxy Chlorpromazine (hydrochloride) | 51938-11-5 | >98.00% | |
An active metabolite of chlorpromazine | ||||
| GC48659 | Umbelliprenin | 532-16-1; 23838-17-7 | >98.00% | |
A prenylated coumarin with diverse biological activities | ||||
| GC48720 | Griseofulvic Acid | 469-54-5 | >95.00% | |
A metabolite of griseofulvin | ||||
| GC48721 | 6-O-Demethyl Griseofulvin | 20168-88-1 | >95.00% | |
A metabolite of griseofulvin | ||||
| GC48738 | (±)12-HETE-d8 | 2525175-25-9 | >99.00% | |
An internal standard for the quantification of 12-HETE | ||||
| GC48739 | (±)15-HETE-d8 | 2525175-31-7 | >99.00% | |
An internal standard for the quantification of 15-HETE | ||||
| GC48804 | N-desmethyl Olanzapine | 161696-76-0 | >95.00% | |
A major metabolite of olanzapine | ||||
| GC48850 | Carbazomycin C | 108073-62-7 | >95.00% | |
A bacterial metabolite with diverse biological activities | ||||
| GC48893 | Carbazomycin B | 75139-38-7 | >95.00% | |
A bacterial metabolite with diverse biological activities | ||||
| GC48894 | SIH (Salinazid) | 495-84-1 | >98.00% | |
An iron chelator | ||||
| GC48924 | TFM | 88-30-2 | >98.00% | |
A piscicide | ||||
| GC48948 | α-Ketoglutaric Acid (sodium salt) | 22202-68-2 | >98.00% | |
An intermediate in the citric acid cycle | ||||
| GC48972 | Resolvin E2 | 865532-70-3 | >95.00% | |
A specialized pro-resolving mediator | ||||