Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC48979Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)纯度: >95.00%
A substrate of multidrug resistance protein 2
- GC49022Didanosine-d2CAS: 69655-05-6纯度: >99.00%
An internal standard for the quantification of didanosine
- GC49108Racecadotril-d5CAS: 1246815-11-1纯度: >99.00%
An internal standard for the quantification of racecadotril
- GC491592-(1-Piperazinyl)pyrimidineCAS: 20980-22-7纯度: >98.00%
An α 2 -AR antagonist and active metabolite of azapirones
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC48979 | Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate) | - | >95.00% | |
A substrate of multidrug resistance protein 2 | ||||
| GC48989 | LTX-315 (trifluoroacetate salt) | - | >95.00% | |
A synthetic cationic amphiphilic peptide | ||||
| GC48993 | Protectin D1-d5 | - | >99.00% | |
An internal standard for the quantification of protectin D1 | ||||
| GC49017 | 8-hydroxy Amoxapine | 61443-78-5 | >95.00% | |
A metabolite of amoxapine | ||||
| GC49022 | Didanosine-d2 | 69655-05-6 | >99.00% | |
An internal standard for the quantification of didanosine | ||||
| GC49051 | 7-hydroxy Methotrexate | 5939-37-7 | >98.00% | |
A metabolite of methotrexate | ||||
| GC49098 | Olsalazine-13C6 | - | >98.00% | |
An internal standard for the quantification of olsalazine | ||||
| GC49100 | Desmethyl Ofloxacin (hydrochloride) | 402930-70-5 | >98.00% | |
A metabolite of ofloxacin | ||||
| GC49108 | Racecadotril-d5 | 1246815-11-1 | >99.00% | |
An internal standard for the quantification of racecadotril | ||||
| GC49111 | Carbamazepine 10,11-epoxide | 36507-30-9 | >98.00% | |
An active metabolite of carbamazepine | ||||
| GC49115 | Desacetylcefotaxime (potassium salt) | - | >95.00% | |
An active metabolite of cefotaxime | ||||
| GC49118 | 10-hydroxy Warfarin | 83219-99-2 | >95.00% | |
A metabolite of (R)-warfarin | ||||
| GC49119 | 5-hydroxy Flunixin | 75369-61-8 | >95.00% | |
A metabolite of flunixin | ||||
| GC49127 | 4-oxo Cyclophosphamide | 27046-19-1 | >95.00% | |
An inactive metabolite of cyclophosphamide | ||||
| GC49130 | Hydroxy Celecoxib | 170571-00-3 | >95.00% | |
An inactive metabolite of celecoxib | ||||
| GC49131 | Dehydro Warfarin | 67588-18-5 | >95.00% | |
A metabolite of (±)-warfarin | ||||
| GC49133 | N-hydroxy Riluzole | 179070-90-7 | >95.00% | |
A metabolite of riluzole | ||||
| GC49142 | Isorhoifolin | 552-57-8 | >98.00% | |
A flavonoid glycoside with diverse biological activities | ||||
| GC49147 | Carboxyphosphamide | 22788-18-7 | >95.00% | |
An inactive metabolite of cyclophosphamide | ||||
| GC49152 | Celecoxib Carboxylic Acid | 170571-01-4 | >95.00% | |
An inactive metabolite of celecoxib | ||||
| GC49156 | Etodolac Acyl Glucuronide | 79541-43-8 | >90.00% | |
A phase II metabolite of etodolac | ||||
| GC49157 | rac-5-carboxy Tolterodine | 1076199-77-3 | >98.00% | |
An inactive metabolite of tolterodine | ||||
| GC49159 | 2-(1-Piperazinyl)pyrimidine | 20980-22-7 | >98.00% | |
An α 2 -AR antagonist and active metabolite of azapirones | ||||
| GC49173 | N-Despropyl Ropinirole | 106916-16-9 | >98.00% | |
An active metabolite of ropinirole | ||||