Metabolism(代谢)

Cat.No. 产品名称 Information

GC40438 (±)5(6)-EET

(±)-顺式-5,6-环氧-8(Z),11(Z),14(Z)-二十碳三烯酸

A racemic version of a CYP450 metabolite of arachidonic acid

GC40437 (±)5(6)-DiHET lactone

(±)5,6DiHETrE lactone

A lactone form of (±)5(6)-DiHET

GC40436 (±)18-HETE

(±)18-Hydroxyeicosatetraenoic Acid

A vasodilator of renal arterioles

GC40435 (±)17-HETE

(±)-Hydroxyeicosatetraenoic Acid

A potent inhibitor of proximal tubule ATPase activity

GC40434 (±)16-HETE

(±)16-Hydroxyeicosatetraenoic Acid

A potent inhibitor of proximal tubule ATPase activity

GC40430 (±)14(15)-EET

(±)14,15-EET, (±)14,15-EpETrE

An arachidonic acid metabolite

GC40425 14,15-EE-8(Z)-E

14,15Epoxyeicosa8(Z)enoic Acid

A potent vasodilator

GC40424 14,15-EE-5(Z)-E

14,15Epoxyeicosa5(Z)enoic Acid

An antagonist of EDHF-mediated vasodilation

GC40392 17-phenyl trinor Prostaglandin F2α methyl ester

比马前列素酸甲基酯

A lipophilic analog of 17-phenyl trinor PGF_2α

GC40389 (±)7(8)-DiHDTE

(±)7(8)-DiHDoTE

An oxylipin

GC40388 (±)19(20)-DiHDTE

(±)19(20)-DiHDoTE

An oxylipin

GC40386 (±)11(12)-EpETE

(±)11,12-EEQ, (±)11,12-Epoxyeicosatetraenoic Acid

Epoxygenase metabolite of EPA

GC40384 CAY10410

9,10dihydro15deoxyΔ12,14PGJ2, 9,10dihydro15deoxyΔ12,14Prostaglandin J2

A less electrophilic, isosteric analog of 15-deoxy-D12,14-PGJ₂

GC40377 20-HEPE An EPA metabolite

GC40365 (±)8(9)-EpETE

(±)8,9-EEQ, (±)8,9-epoxy Eicosatetraenoic Acid

Epoxygenase metabolite of EPA

GC40363 (±)5(6)-DiHETE lactone A lactone form of (±)5(6)-DiHETE

GC40360 (±)14(15)-EpETE

(±)14,15 EEQ, (±)14,15epoxy Eicosatetraenoic Acid

An EPA congener of (±)14(15)-EpETrE with EDHF activity

GC40341 Tetrahydro-11-deoxy Cortisol

四氢化-11-脱氧皮质醇

A metabolite of 11-deoxycortisol

GC40338 9-deoxy-9-methylene Prostaglandin E2

9deoxy9methylene PGE2

A stable, isosteric analog of PGE₂

GC40334 Myristoleic Acid methyl ester

肉豆蔻脑酸甲酯

Methyl ester of the cytotoxin myristoleic acid

GC40328 1,7-Dimethyluric Acid

1,7-二甲基尿酸

A caffeine metabolite

GC40319 10-PAHSA A FAHFA with anti-diabetic potential

GC40301 Tamoxifen N-oxide

他莫昔芬N-氧化物

A metabolite of tamoxifen

GC40299 L-(+)-Erythrose

L-赤藓糖

An aldotetrose carbohydrate

GC40298 N-acetyl-5-Aminosalicylic Acid

5-乙酰氨基水杨酸

A metabolite of 5-ASA and sulfasalazine

GC40286 (E,Z)-2-propyl-2-Pentenoic Acid

2-丙基-2-戊烯酸

A valproic acid metabolite

GC40282 (+)-5-trans Cloprostenol

5,6-反式-氯前列醇

Less active isomer of (+)-Cloprostenol

GC40279 (±)11(12)-DiHET

(±)11,12DiHETrE

An epoxide metabolite and potent vasodilator

GC40272 (±)8(9)-DiHET

(±)8,9DiHETrE

A CYP450 metabolite of arachidonic acid

GC40268 (±)14(15)-DiHET

(±)14,15DiHETrE

A urinary metabolite of (±)14(15)-EET

GC19536 6'-Sialyllactose Sodium Salt

6'-唾液乳糖钠盐,6'-N-Acetylneuraminyl-D-lactose

A major milk oligosaccharide

GC34939 UAMC-3203 hydrochloride A ferroptosis inhibitor

GC34895 D159687 D159687是一种选择性PDE4D抑制剂。

GC34705 PDE2/PDE10-IN-1 PDE2/PDE10-IN-1是一种磷酸二酯酶PDE2和PDE10抑制剂，IC50分别为29和480nM。

GC34634 JG-98

3-苄基-2-((Z)-((E)-5-(6-氯-3-甲基苯并[D]噻唑-2(3H)-亚基)-3-乙基-4-氧代噻唑啉-2-亚基)甲基)噻唑-3-鎓氯化物

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

GC34623 IACS-8968 S-enantiomer IACS-8968(S-enantiomer)是IACS-8968的S型对映异构体。IACS-8968是IDO和TDO的双抑制剂，其pIC50s值分别为6.43，<5。

GC34622 IACS-8968 R-enantiomer IACS-8968(R-enantiomer)是IACS-8968的R型对映异构体。IACS-8968是IDO和TDO的双抑制剂，其pIC50s值分别为6.43，<5。

GC34621 IACS-8968 IACS-8968是IDO和TDO的双抑制剂，其pIC50s值分别为6.43，<5。

GC34613 HFI-142 HFI-142是胰岛素调节性氨基肽酶(IRAP)抑制剂，ki值为2.01μM。

GC34562 DT-061 DT-061（SMAP）是一种蛋白磷酸酶2A（PP2A）的口服生物活性激活剂，能够用于KRAS（Kirsten rat sarcoma viral oncogene，一种鼠类肉瘤病毒癌基因）突变和MYC（myelocytomatosis oncogene，骨髓细胞瘤癌基因）驱动的肿瘤的相关研究。