P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
P450 相关产品(439)
- GC17645AbirateroneCAS: 154229-19-3纯度: >99.50%
Abiraterone是一种FDA批准的CYP17A1抑制剂，已获批准用于去势抵抗性前列腺癌（CRPC）的治疗。
- GC10198Memantine hydrochlorideCAS: 41100-52-1纯度: >98.00%
Memantine hydrochloride是一种非竞争性N-甲基-D-天冬氨酸受体（NMDAR）拮抗剂，IC 50 值为0.5-1μM。
- GC11638SulfaphenazoleCAS: 526-08-9纯度: >99.50% / >98.00% / >98.50%
Sulfaphenazole是一种磺胺类抗菌药物。它竞争性地抑制细菌二氢叶酸合酶，阻断细菌叶酸合成，从而抑制细菌生长和繁殖。
- GC13470RhapontigeninCAS: 500-65-2纯度: >98.00% / >99.50%
Rhapontigenin（丹叶大黄素）是一种有效的细胞色素P4501A1选择性灭活剂，IC 50 为0.4μM，对P4501A1的选择性分别是P4501A2和P4501B1的400倍和23倍。
- GC14486(S)-MephenytoinCAS: 70989-04-7纯度: >98.00%
S-Mephenytoin (5-phenyl-5-ethyl-N-methylhydantoin) 是一种抗惊厥药，通过 N-去甲基化和 4-羟基化（芳环）代谢。
- GC147811-Aminobenzotriazole (ABT)CAS: 1614-12-6纯度: >99.50%
1-Aminobenzotriazole (ABT)是具有口服活性的细胞色素P450（CYP）的非特异性和不可逆抑制剂。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10999 | Avasimibe | 166518-60-1 | >99.50% / >98.00% | |
Avasimibe是一种选择性口服酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂（IC 50 =12μmol/L）。 | ||||
| GC11108 | Abiraterone acetate | 154229-18-2 | >99.50% | |
A CYP17A1 inhibitor | ||||
| GC12280 | PF-4981517 | 1390637-82-7 | >99.00% | |
A potent, selective inhibitor of CYP3A4 | ||||
| GC16575 | Alizarin | 72-48-0 | >99.00% | |
A CYP450 inhibitor | ||||
| GC17337 | Ketoconazole | 65277-42-1 | >99.50% | |
A triazole antifungal agent | ||||
| GC17645 | Abiraterone | 154229-19-3 | >99.50% | |
Abiraterone是一种FDA批准的CYP17A1抑制剂，已获批准用于去势抵抗性前列腺癌（CRPC）的治疗。 | ||||
| GC10136 | Tienilic Acid | 40180-04-9 | - | |
Suicide substrate of CYP 2C9 | ||||
| GC10198 | Memantine hydrochloride | 41100-52-1 | >98.00% | |
Memantine hydrochloride是一种非竞争性N-甲基-D-天冬氨酸受体（NMDAR）拮抗剂，IC 50 值为0.5-1μM。 | ||||
| GC10240 | Atazanavir sulfate (BMS-232632-05) | 229975-97-7 | >99.50% | |
An inhibitor of HIV-1 protease | ||||
| GC11155 | Omeprazole sulfone | 88546-55-8 | - | |
The major metabolite of omeprazole | ||||
| GC11170 | Choline Fenofibrate | 856676-23-8 | >98.00% | |
非诺贝特胆碱 (ABT-335) 是一种非诺贝酸的胆碱盐，可在胃肠道中释放游离的非诺贝酸。 | ||||
| GC11540 | HET0016 | 339068-25-6 | >99.50% / >98.50% | |
HET0016 是一种高选择性的20-羟基花生四烯酸（20-HETE）合成酶抑制剂，对重组CYP4A1、CYP4A2和CYP4A3催化20-HETE合成作用的IC 50 值分别为17.7nM, 12.1nM和20.6nM。 | ||||
| GC11638 | Sulfaphenazole | 526-08-9 | >99.50% / >98.00% / >98.50% | |
Sulfaphenazole是一种磺胺类抗菌药物。它竞争性地抑制细菌二氢叶酸合酶，阻断细菌叶酸合成，从而抑制细菌生长和繁殖。 | ||||
| GC11758 | 4-phenyl-5-methyl-1,2,3-Thiadiazole | 64273-28-5 | - | |
CYP2B4 and CYP2E1 inhibitor | ||||
| GC12250 | Fenofibrate | 49562-28-9 | >99.50% / >99.00% / >97.00% | |
A PPARα agonist | ||||
| GC12262 | 2-Phenyl-2-(1-piperidinyl)propane | 92321-29-4 | - | |
A selective inhibitor of CYP2B6 | ||||
| GC12892 | Doxepin (hydrochloride) | 1229-29-4 | >98.00% | |
A tricyclic antidepressant | ||||
| GC12945 | Atazanavir | 198904-31-3 | - | |
An inhibitor of HIV-1 protease | ||||
| GC13362 | TOK-001 | 851983-85-2 | >99.50% | |
A CYP17 inhibitor | ||||
| GC13470 | Rhapontigenin | 500-65-2 | >98.00% / >99.50% | |
Rhapontigenin（丹叶大黄素）是一种有效的细胞色素P4501A1选择性灭活剂，IC 50 为0.4μM，对P4501A1的选择性分别是P4501A2和P4501B1的400倍和23倍。 | ||||
| GC13836 | 2,3-dihydrothieno-Thiadiazole Carboxylate | 152467-47-5 | - | |
Selective CYP450 inhibitor | ||||
| GC14269 | Cobicistat (GS-9350) | 1004316-88-4 | >98.00% | |
An inhibitor of CYP3A | ||||
| GC14486 | (S)-Mephenytoin | 70989-04-7 | >98.00% | |
S-Mephenytoin (5-phenyl-5-ethyl-N-methylhydantoin) 是一种抗惊厥药，通过 N-去甲基化和 4-羟基化（芳环）代谢。 | ||||
| GC14781 | 1-Aminobenzotriazole (ABT) | 1614-12-6 | >99.50% | |
1-Aminobenzotriazole (ABT)是具有口服活性的细胞色素P450（CYP）的非特异性和不可逆抑制剂。 | ||||