GlpBio

P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

P450 相关产品(439)

  • GC14915 structure
    GC14915Gemfibrozil
    CAS: 25812-30-0
    纯度: >99.50%

    A PPARα and PPARγ agonist

  • GC15056 structure
    GC15056β-Nicotyrine
    CAS: 487-19-4
    纯度: >98.00%

    β-Nicotyrine是一种尼古丁的热解产物，可与细胞色素P450 (CYP) isoforms CYP2A6和CYP2A13结合，并能更有效地抑制CYP2A6的活性

  • GC15244 structure
    GC15244Thienyldecyl Isothiocyanate
    CAS: 288323-41-1

    An antiproliferative isothiocyanate

  • GC15445 structure
    GC15445TMS
    CAS: 24144-92-1
    纯度: >99.00% / >98.00%

    TMS（2,3',4,5'-tetramethoxystilbene）是一种特异性强效的CYP1B1抑制剂，IC 50 值为6±2nmol/L。

  • GC16256 structure
    GC16256BVT 948
    CAS: 39674-97-0
    纯度: >98.50%

    An inhibitor of protein tyrosine phosphatases

  • GC16259 structure
    GC16259SKF 525A (hydrochloride)
    CAS: 62-68-0
    纯度: >99.50%

    A nonspecific CYP450 inhibitor

  • GC16423 structure
    GC16423Monoacetylphloroglucinol
    CAS: 480-66-0
    纯度: >98.00% / >99.00%

    单乙酰间苯三酚（2,4,6-三羟基苯乙酮）是从姜黄中提取的苯乙酮糖苷的苷元部分，具有降低胆固醇的活性。

  • GC16550 structure
    GC16550Diosmetin
    CAS: 520-34-3
    纯度: >99.50%

    A flavonoid with diverse biological activities

  • GC16707 structure
    GC16707Isavuconazole
    CAS: 241479-67-4
    纯度: >98.00%

    A broad-spectrum triazole antifungal agent

  • GC16751 structure
    GC16751Chlorzoxazone
    CAS: 95-25-0
    纯度: >99.50%

    A centrally acting muscle relaxant

  • GC16754 structure
    GC16754Clarithromycin
    CAS: 81103-11-9
    纯度: >98.00%

    Clarithromycin是一种大环内酯类抗生素，通过抑制细菌蛋白质合成发挥作用，与细菌核糖体的50S亚基结合，阻止肽链延长，从而抑制细菌生长。

  • GC16951 structure
    GC16951Stiripentol
    CAS: 49763-96-4
    纯度: >99.50%

    An antiepileptic compound

  • GC17063 structure
    GC17063Talarozole
    CAS: 201410-53-9
    纯度: >98.00% / >97.50%

    Talarozole (R115866) 是一种口服全身性全反式维甲酸代谢阻断剂 (RAMBA)，可增加内源性全反式维甲酸 (RA) 的细胞内水平。

  • GC17112 structure
    GC17112Uniconazole
    CAS: 83657-22-1
    纯度: >98.50%

    A plant growth regulator

  • GC17411 structure
    GC17411Metyrapone
    CAS: 54-36-4
    纯度: >98.00%

    Metyrapone是一种强效的口服11β羟化酶抑制剂和自噬激活剂，还能抑制醛固酮的产生。Metyrapone可用于抑郁症、动脉粥样硬化和癌症的研究。

  • GC18219 structure
    GC182196-hydroxy Warfarin
    CAS: 17834-02-5
    纯度: >98.00%

    A phase I metabolite of (+)-warfarin

  • GC18252 structure
    GC18252Diallyl Sulfide
    CAS: 592-88-1
    纯度: >98.00%

    An organosulfur compound

  • GC18286 structure
    GC18286(R)-Mephenytoin
    CAS: 71140-51-7
    纯度: >98.00%

    An enantiomer of mephenytoin

  • GC18335 structure
    GC183356β-hydroxy Dexamethasone
    CAS: 55879-47-5

    A metabolite of dexamethasone

  • GC18425 structure
    GC184254-hydroxy Atorvastatin lactone
    CAS: 163217-70-7

    A metabolite of atorvastatin

  • GC18460 structure
    GC18460Roquefortine C
    CAS: 58735-64-1

    A mycotoxin

  • GC18527 structure
    GC185274'-hydroxy Flurbiprofen
    CAS: 52807-12-2

    A major active metabolite of flurbiprofen

  • GC18539 structure
    GC185394-Hydroxyretinoic acid (4-HRA)
    CAS: 66592-72-1
    纯度: >98.00%

    4-Hydroxyretinoic acid (4-HRA)是一种天然存在的，由全反式视黄酸（ATRA）经细胞色素P450酶代谢生成的主要代谢产物。

  • GC18582 structure
    GC185825'-hydroxy Meloxicam
    CAS: 130262-92-9

    A metabolite of meloxicam