GlpBio

P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

P450 相关产品(439)

  • GC36754 structure
    GC36754N-Nornuciferine
    CAS: 4846-19-9
    纯度: >98.00%

    An alkaloid with cholinesterase inhibitory activity

  • GC36822 structure
    GC36822Oteseconazole
    CAS: 1340593-59-0
    纯度: >99.50%

    Oteseconazole (VT-1161) 是一种有效、可口服的抗真菌剂，有效结合并抑制白色念球菌的 CYP51 (Kd，<39 nM)，但对人 CYP51 无明显作用。

  • GC37061 structure
    GC37061Quilseconazole
    CAS: 1340593-70-5

    Quilseconazole (VT-1129) 是一种有效、可口服的真菌 Cyp51 (fungal Cyp51) 抑制剂，能够与隐球菌的 Cyp51 紧密结合，但对人 Cyp51 的抑制作用很弱。

  • GC37631 structure
    GC37631Seviteronel
    CAS: 1610537-15-9
    纯度: >99.50%

    Seviteronel (VT-464) 是 CYP17 裂解酶抑制剂，对h-Lyase的 IC50 为 69 nM。

  • GC37632 structure
    GC37632Seviteronel racemate
    CAS: 1375603-36-3
    纯度: >98.00%

    Seviteronel racemate (VT-464 racemate) 消旋体是 Seviteronel (VT-464) 的外消旋形式。

  • GC37727 structure
    GC37727Talarozole R enantiomer
    CAS: 870093-23-5

    Talarozole R enantiomer是一个强的，有选择性的细胞色素P450，CYP26的抑制剂。

  • GC38421 structure
    GC38421Phillyrin (Forsythin)
    CAS: 487-41-2
    纯度: >98.50%

    A lignan with diverse biological activities

  • GC38554 structure
    GC38554Liarozole dihydrochloride
    CAS: 1883548-96-6
    纯度: >99.00%

    Liarozole dihydrochloride 是一种 P-450 抑制剂，视黄酸 (RA) 代谢阻断剂可抑制 RA 代谢，从而增加活跃产生 RA 的细胞中的细胞内 RA 水平。

  • GC38623 structure
    GC38623Fraxinol
    CAS: 486-28-2

    A coumarin

  • GC38681 structure
    GC38681Cedrol
    CAS: 77-53-2
    纯度: >98.00%

    A sesquiterpene alcohol

  • GC38758 structure
    GC38758Clomethiazole
    CAS: 533-45-9
    纯度: >98.00%

    Chlormethiazole 是一种有效的口服 GABAA 激动剂。 Chlormethiazole 还可以抑制人肝微粒体中的细胞色素 P450 亚型: CYP2A6 和 CYP2E1。Chlormethiazole 有抗惊厥作用，具有治疗惊厥性癫痫的潜力。

  • GC39168 structure
    GC39168GSK2945 hydrochloride
    纯度: >99.50%

    GSK2945 hydrochloride 是一类叔胺，是一种高度特异性的 Rev-erbα/REV-ERBα (小鼠/人反向成红细胞病病毒α) 拮抗剂， 其 EC50 值分别为 21.5 μM 和 20.8 μM。GSK2945 hydrochloride 可增强胆固醇 7α-羟化酶 (CYP7A1) 水平和胆固醇代谢。

  • GC39746 structure
    GC39746(3S,5S)-Atorvastatin
    CAS: 501121-34-2
    纯度: >95.00%

    An enantiomer of atorvastatin

  • GC40112 structure
    GC40112(&#177;)-Climbazole-d4
    CAS: 1185117-79-6
    纯度: >99.00%

    An internal standard for the quantification of climbazole

  • GC40228 structure
    GC40228Fluvastatin-d6 (sodium salt)
    纯度: >95.00%

    An internal standard for the quantification of fluvastatin

  • GC40258 structure
    GC40258Tetrahydropiperine
    CAS: 23434-88-0
    纯度: >97.00%

    A derivative of piperine

  • GC40268 structure
    GC40268(&#177;)14(15)-DiHET
    纯度: >98.00%

    A urinary metabolite of (±)14(15)-EET

  • GC40272 structure
    GC40272(&#177;)8(9)-DiHET
    CAS: 192461-96-4
    纯度: >98.00%

    A CYP450 metabolite of arachidonic acid

  • GC40279 structure
    GC40279(&#177;)11(12)-DiHET
    纯度: >98.00%

    An epoxide metabolite and potent vasodilator

  • GC40301 structure
    GC40301Tamoxifen N-oxide
    CAS: 75504-34-6
    纯度: >98.00%

    A metabolite of tamoxifen

  • GC40341 structure
    GC40341Tetrahydro-11-deoxy Cortisol
    CAS: 68-60-0
    纯度: >95.00%

    A metabolite of 11-deoxycortisol

  • GC40360 structure
    GC40360(&#177;)14(15)-EpETE
    CAS: 131339-24-7
    纯度: >90.00%

    An EPA congener of (±)14(15)-EpETrE with EDHF activity

  • GC40363 structure
    GC40363(&#177;)5(6)-DiHETE lactone
    纯度: >90.00%

    A lactone form of (±)5(6)-DiHETE

  • GC40365 structure
    GC40365(&#177;)8(9)-EpETE
    CAS: 851378-93-3
    纯度: >95.00%

    Epoxygenase metabolite of EPA