P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for P450

Cat.No. 产品名称 Information
GC45239 δ4-Abiraterone
阿比特龙代谢物,Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite
An active metabolite of abiraterone
GC45208 α-hydroxy Metoprolol
Α-羟基美托洛尔
An active metabolite of metoprolol
GC45151 Voriconazole N-oxide
伏立康唑N-氧化物
A major metabolite of voriconazole
GC45023 tetranor-12(R)-HETE
8(R)-HHxTrE, tetranor-12(R)-Hydroxyeicosatetraenoic Acid, 2,3,4,5-Tetranor 12(R)-HETE
A metabolite of 12(R)-HETE
GC44975 SW203668 (trifluoroacetate salt) An irreversible inhibitor of stearoyl-CoA desaturase
GC44917 Sorafenib N-oxide
索拉非尼N氧化物
An active metabolite of sorafenib
GC44907 S-NEPC A colorimetric substrate for sEH
GC44882 Seneciphylline
千里光菲灵碱
An alkaloid with diverse biological activities
GC44819 Resorufin benzyl ether
7-苄氧基试卤灵
A fluorometric substrate for CYP450-linked enzymes
GC44799 Quinidine N-oxide A quinidine metabolite
GC44668 Posaconazole D-Glucuronide
Posaconazole N-β-D-Glucuronide
A metabolite of posaconazole
GC44555 Pantoprazole sulfone
泮托拉唑杂质A
A pantoprazole metabolite
GC44554 Pantoprazole Sulfide
泮托拉唑硫醚
A pantoprazole metabolite
GC44492 O-Desmethyl Metoprolol
O-去甲基美托洛尔
A major active metabolite of metoprolol
GC44451 Norfluoxetine (hydrochloride)
去甲氟西汀,Desmethylfluoxetine
Norfluoxetine (hydrochloride)是Fluoxetine在肝脏中通过N-去甲基化产生的活性代谢物，具有口服活性。
GC44351 N-Desmethyl Sildenafil (citrate) A major metabolite of sildenafil
GC44350 N-Desmethyl Sildenafil
N-去甲基西地那非,Desmethylsildenafil; UK-103,320
A major metabolite of sildenafil
GC44348 N-desmethyl Bendamustine
盐酸苯达莫司汀乙酯水解杂质
An active metabolite of bendamustine
GC44345 N-Desethyl Vardenafil
N-去乙基伐地那非
A vardenafil metabolite
GC44299 N-Acetyl-4-benzoquinone imine
N-乙酰基-4-苯醌亚胺
A reactive CYP450 metabolite of acetaminophen
GC44033 Lansoprazole sulfone
兰索拉唑磺酸盐
A metabolite of lansoprazole
GC43879 Hydroxy Ebastine An ebastine metabolite
GC43743 Gemfibrozil 1-O-β-Glucuronide
吉非罗齐酰基β-D-葡萄糖醛酸
A major metabolite of gemfibrozil
GC43627 Erythromycin lactobionate
红霉素乳糖酸盐
Erythromycin lactobionate是红霉素的水溶性酯衍生物，属于大环内酯类抗生素。Erythromycin lactobionate具有广泛的抗菌谱，对肺炎链球菌、化脓性链球菌、金黄色葡萄球菌以及一些非典型病原体如肺炎支原体和肺炎衣原体等均有效。
GC43626 Erythromycin A N-oxide
红霉素A氧化物
A potential impurity in commercial preparations of erythromycin
GC43621 Epoxy Fluor 7 A sensitive fluorescent substrate for soluble epoxide hydrolase
GC43440 Dibenzylfluorescein
DBF, NSC 645658
Dibenzylfluorescein是一种荧光探针，激发波长为485nm，发射波长为535nm。
GC43401 Dehydro Nifedipine
4-(2硝基苯基)-2,6-二甲基吡啶-3,5二羧酸二甲酯
An active metabolite of nifedipine
GC43400 Dehydro Aripiprazole (hydrochloride)
脱氢阿立哌唑盐酸盐
The primary, active metabolite of aripiprazole
GC43278 Clindamycin Sulfoxide
克林霉素亚砜
An active metabolite of clindamycin
GC43158 CAY10462 A potent, selective 20-HETE synthase inhibitor
GC42888 Azamulin
阿扎莫林,Antibiotic TDM 85-530
A selective CYP3A inhibitor
GC42887 Axitinib Sulfoxide
阿西替尼杂质A
A major inactive metabolite of axitinib
GC42879 Avanafil metabolite M4 An active metabolite of avanafil
GC42878 Avanafil metabolite M16 A major inactive metabolite of avanafil
GC42626 8-hydroxy Efavirenz
8-羟基依法韦伦
A major metabolite of efavirenz
GC42586 6α-hydroxy Paclitaxel
6-羟基泰素
A metabolite of paclitaxel
GC42584 6-O-desmethyl Donepezil
6-O-去甲基多奈哌齐
An active metabolite of donepezil
GC42580 6-hydroxy Chlorzoxazone
6-.羟基氯唑沙宗,NSC 24955
6-hydroxy Chlorzoxazone是Chlorzoxazone在体内的主要代谢产物。6-hydroxy Chlorzoxazone主要通过肝脏细胞色素P450酶系统形成，在生化研究中常作为探针用于定量评估CYP2E1的活性。
GC42551 5-hydroxymethyl Tolterodine (formate)
5-羟甲基托特罗定
An active metabolite of tolterodine and fesoterodine
GC42550 5-hydroxy-6-methoxy (S)-Duloxetine
度洛西汀杂质
A metabolite of (S)-duloxetine
GC42546 5-hydroxy Diclofenac
5-羟基双氯芬酸
An active metabolite of diclofenac
GC42409 4-hydroxy Nebivolol (hydrochloride) A major metabolite of nebivolol
GC42405 4-hydroxy Atorvastatin (calcium salt)
4-羟基阿托伐他汀（钙盐）
A metabolite of atorvastatin
GC42402 4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)
LY550408
An inactive metabolite of (S)-duloxetine
GC42085 20-hydroxy N-Arachidonoyl Taurine A potential CYP450 metabolite of N-arachidonoyl-taurine
GC42083 20-HETE Ethanolamide
20-hydroxy AEA, 20-hydroxy Arachidonoyl Ethanolamide, 20-Hydroxyeicosatetraenoic Acid Ethanolamide
A putative CYP450 metabolite of AEA
GC41945 16-hydroxy Hexadecanoic Acid
16-羟基棕榈酸
CYP450 metabolite of palmitic acid
GC41837 1,3,7-Trimethyluric Acid
1,3,7-三甲基尿酸,8-oxo Caffeine, NSC 11259
A metabolite of caffeine
GC41720 (R)-Omeprazole (sodium salt)
5-甲氧基-2-[(4-甲氧基-3,5-二甲基-2-吡啶基)-甲基]-3H-苯并咪唑钠盐
An inactive isomer of a gastric proton pump inhibitor