(+)-Cedrol is a sesquiterpene alcohol that has been used in Cannabis testing and has diverse biological activities.1 It inhibits the growth of L. sulphureus, G. trabeum, L. betulina, and T. versicolor wood decay fungi when used at a concentration of 100 μg/ml.2 (+)-Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively).3 In vivo, (+)-cedrol (200 mg/kg) prevents hair follicle dystrophy and reduces hair loss in a mouse model of alopecia induced by cyclophosphamide .4 (+)-Cedrol-loaded nanostructured lipid particles reduce peritoneal mast cell degranulation, a component of the type I anaphylactic response, induced by compound 48/80 in mice.5
1.Fischedick, J.T.Identification of terpenoid chemotypes among high (–)-trans-Δ9-tetrahydrocannabinol-producing Cannabis sativa L. cultivarsCannabis Cannabinoid Res.2(1)34-47(2017) 2.Cheng, S.S., Chung, M.J., Lin, C.Y., et al.Phytochemicals from Cunninghamia konishii Hayata act as antifungal agentsJ. Agric. Food Chem.60(1)124-128(2012) 3.Jeong, H.U., Kwon, S.S., Kong, T.Y., et al.Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomesJ. Toxicol. Environ. Health A77(22-24)1522-1532(2014) 4.Chen, S.S., Zhang, Y., Lu, Q.L., et al.Preventive effects of cedrol against alopecia in cyclophosphamide-treated miceEnviron. Toxicol. Pharmacol.46270-276(2016) 5.Chakraborty, S., Kar, N., Kumari, L., et al.Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in miceInt. J. Nanomedicine124849-4868(2017)