Fungal
Fungal(真菌)
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
Fungal 相关产品(356)
- GC10090Nystatin (Fungicidin)CAS: 1400-61-9纯度: >98.00%
Nystatin (Fungicidin) 是一种口服活性多烯抗真菌抗生素，对酵母菌和支原体有效。
- GC10303Caspofungin AcetateCAS: 179463-17-3纯度: >99.50% / >98.00%
Caspofungin Acetate是棘白菌素（echinocandins）成员，是一种通过抑制真菌细胞壁β(1,3)- d -葡聚糖合成酶而靶向曲霉和念珠菌的脂肽类抗真菌化合物。
- GC11120Ciclopirox ethanolamineCAS: 41621-49-2纯度: >99.50%
An iron chelator, antifungal, and anticancer agent
- GC11512FluconazoleCAS: 86386-73-4纯度: >99.00%
Fluconazole是一种三唑类广谱抗真菌药物，可抑制 C. albicans （IC 99 =0.20μg/mL）和 Candida kefyr （IC 99 =0.39μg/mL）。
- GC13079VoriconazoleCAS: 137234-62-9纯度: >99.50%
Voriconazole是一种强效竞争性抑制剂，可抑制CYP2B6（IC 50 =1.71μM）、CYP2C9（IC 50 =3.62μM）、CYP2C19（IC 50 =5.25μM）和CYP3A（IC 50 =2.90μM）。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10090 | Nystatin (Fungicidin) | 1400-61-9 | >98.00% | |
Nystatin (Fungicidin) 是一种口服活性多烯抗真菌抗生素，对酵母菌和支原体有效。 | ||||
| GC10120 | Phenothiazine | 92-84-2 | >99.00% | |
吩噻嗪是一种具有杀虫、杀真菌、抗菌和驱虫活性的抗生素。 | ||||
| GC10132 | Ciclopirox | 29342-05-0 | >99.50% | |
An iron chelator, antifungal, and anticancer agent | ||||
| GC10303 | Caspofungin Acetate | 179463-17-3 | >99.50% / >98.00% | |
Caspofungin Acetate是棘白菌素（echinocandins）成员，是一种通过抑制真菌细胞壁β(1,3)- d -葡聚糖合成酶而靶向曲霉和念珠菌的脂肽类抗真菌化合物。 | ||||
| GC10337 | Tolnaftate | 2398-96-1 | >99.50% | |
A thiocarbamate antifungal agent | ||||
| GC10541 | Miconazole | 22916-47-8 | >99.50% | |
Miconazole (R18134) 是一种咪唑类抗真菌剂。 | ||||
| GC10625 | Fenticonazole Nitrate | 73151-29-8 | >99.00% | |
An antimicrobial imidazole | ||||
| GC10954 | Leptomycin B | 87081-35-4 | >99.50% | |
Leptomycin B (LMB)是染色体区域维持1 (CRM1)的抑制剂,CRM1是核蛋白输出蛋白之一。 | ||||
| GC11056 | Itraconazole | 84625-61-6 | >99.00% | |
An antifungal agent and hedgehog pathway inhibitor | ||||
| GC11120 | Ciclopirox ethanolamine | 41621-49-2 | >99.50% | |
An iron chelator, antifungal, and anticancer agent | ||||
| GC11363 | Naftifine HCl | 65473-14-5 | >99.00% | |
An antifungal agent | ||||
| GC11460 | Climbazole | 38083-17-9 | >98.50% | |
An imidazole antifungal agent | ||||
| GC11512 | Fluconazole | 86386-73-4 | >99.00% | |
Fluconazole是一种三唑类广谱抗真菌药物，可抑制 C. albicans （IC 99 =0.20μg/mL）和 Candida kefyr （IC 99 =0.39μg/mL）。 | ||||
| GC11816 | Posaconazole hydrate | 1198769-38-8 | - | |
An antifungal agent | ||||
| GC11909 | Sulconazole Nitrate | 61318-91-0 | >98.00% | |
An azole antifungal | ||||
| GC12048 | Filipin III | 480-49-9 | >98.00% / >90.00% | |
An isomeric polyene macrolide | ||||
| GC12381 | Natamycin | 7681-93-8 | >99.00% | |
A macrolide polyene antifungal agent | ||||
| GC12404 | (+)-Ketoconazole | 65277-42-1 | >99.50% | |
A triazole antifungal agent | ||||
| GC12754 | Anidulafungin | 166663-25-8 | >99.00% | |
Anidulafungin是一种棘白菌素类抗真菌药物。 | ||||
| GC12797 | Benzoic Acid | 65-85-0 | >98.00% | |
苯甲酸是一种天然存在于许多植物中的芳香醇，是食品、饮料、化妆品等产品的常见添加剂。 | ||||
| GC12984 | Butoconazole nitrate | 64872-77-1 | >99.50% | |
An imidazole antifungal agent | ||||
| GC13079 | Voriconazole | 137234-62-9 | >99.50% | |
Voriconazole是一种强效竞争性抑制剂，可抑制CYP2B6（IC 50 =1.71μM）、CYP2C9（IC 50 =3.62μM）、CYP2C19（IC 50 =5.25μM）和CYP3A（IC 50 =2.90μM）。 | ||||
| GC13207 | Butenafine HCl | 101827-46-7 | >98.00% | |
An antifungal agent | ||||
| GC13311 | Triclosan | 3380-34-5 | - | |
Triclosan 是一种广谱抗菌剂。 | ||||