GlpBio

Tolnaftate

目录号: GC10337纯度: >99.50%同义词: 托萘酯; NP-27
A thiocarbamate antifungal agent
Tolnaftate
Cas No.: 2398-96-1
规格价格库存数量操作
50mg¥494.00现货
1
10mM (in 1mL DMSO)¥357.00现货
1
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文献被引

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产品描述 Description

Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .

Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans[1]. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid[2].

References:
[1]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60.
[2]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
2398-96-1
同义词
托萘酯; NP-27
化学名
O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
SMILES
CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2
分子式
C19H17NOS
分子量
307.41 g/mol
溶解性
≥ 12.7mg/mL in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol