GlpBio

Fungal

Fungal(真菌)

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品(356)

  • GC32308 structure
    GC32308Bactenecin (Bactenecin, bovine)
    CAS: 116229-36-8
    纯度: >98.00%

    Bactenecin (Bactenecin, bovine) (Bactenecin (Bactenecin, bovine), bovine) 是一种从牛嗜中性粒细胞中分离出来的有效的 12-aa 环状抗菌肽。

  • GC32312 structure
    GC32312Magainin 1
    CAS: 108433-99-4

    Magainin1是在非洲爪蟾皮肤中发现的抗微生物多肽。

  • GC32321 structure
    GC32321Vibunazole (BAY-N-7133)
    CAS: 80456-55-9

    Vibunazole是一种新型的抗真菌唑。

  • GC32322 structure
    GC32322Xanthyletin
    CAS: 553-19-5
    纯度: >98.00%

    A coumarin

  • GC32324 structure
    GC32324AN2718
    CAS: 174672-06-1
    纯度: >99.50%

    A broad-spectrum antifungal

  • GC32331 structure
    GC32331Carboxin (Carboxine)
    CAS: 5234-68-4
    纯度: >99.50%

    Carboxin (Carbathiin, Vitavax, Kisvax) is a systemic agricultural fungicide and seed protectant. Carboxin inhibits succinate dehydrogenaseactivity .

  • GC32346 structure
    GC32346Fluazinam
    CAS: 79622-59-6
    纯度: >98.00%

    A fungicide

  • GC32347 structure
    GC32347Dermaseptin
    CAS: 136212-91-4

    Dermaseptin是从青蛙皮肤分离的多肽，对细菌，真菌和原生动物表现出有效的抗菌活性。

  • GC32355 structure
    GC32355L-4-Oxalysine hydrochloride
    CAS: 118021-35-5

    L-4-Oxalysinehydrochloride是从中国的链霉菌培养基中分离的天然物质，具有抗癌活性。

  • GC32374 structure
    GC32374Saperconazole (R66905)
    CAS: 110588-57-3

    Saperconazole (R66905) (R66905) 是一种广谱抗真菌三唑类，对曲霉具有有效的活性，MIC90 为 0.19 mg/L。

  • GC32375 structure
    GC323752,3-Dimethoxybenzaldehyde (o-Veratraldehyde)
    CAS: 86-51-1
    纯度: >99.50%

    o-Veratraldehyde (2,3-Dimethoxybenzaldehyde) is used as the materials for the organic synthesis intermediates.

  • GC32379 structure
    GC32379Aliconazole
    CAS: 63824-12-4

    Aliconazole是一种抗真菌(antifungal)咪唑衍生物。

  • GC32386 structure
    GC32386Fludazonium chloride (R23633)
    CAS: 53597-28-7

    Fludazonium chloride (R23633) (R23633) 是一种抗真菌剂，可用于治疗和预防浅表和全身真菌感染。

  • GC32389 structure
    GC323892,4,6-Tribromophenyl caproate
    CAS: 16732-09-5
    纯度: >98.00%

    2,4,6-Tribromophenylcaproate(2,4,6-tribromophenylcaproicacidester)是一种抗真菌剂。

  • GC32391 structure
    GC32391Pyrogallol
    CAS: 87-66-1
    纯度: >99.50%

    A natural oxidant

  • GC32394 structure
    GC32394Chlordantoin (Clodantoin)
    CAS: 5588-20-5

    Chlordantoin (Clodantoin) 是一种抗真菌剂，具有治疗阴道念珠菌病的潜力。

  • GC32676 structure
    GC32676Proanthocyanidins
    CAS: 20347-71-1
    纯度: >95.00%

    Proanthocyanidins是黄酮类生物合成途径的终产物，是单体黄烷-3-醇的低聚物或聚合物。Proanthocyanidins是具有多种药理特性的缩合单宁。

  • GC32943 structure
    GC329433-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid)
    CAS: 646-01-5
    纯度: >98.00%

    3-(Methylthio)propionic acid (3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid) is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro.

  • GC33438 structure
    GC33438Hydroxy Itraconazole
    CAS: 112559-91-8
    纯度: >99.50%

    A metabolite of itraconazole

  • GC33479 structure
    GC33479Hexaconazole ((-)-Hexaconazol)
    CAS: 79983-71-4

    A triazole fungicide

  • GC33538 structure
    GC33538Triacetin (Glyceryl triacetate)
    CAS: 102-76-1
    纯度: >99.50%

    Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) is a triglyceride that is used as an antifungal agent.

  • GC33924 structure
    GC33924Fosfluconazole
    CAS: 194798-83-9
    纯度: >98.00%

    Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

  • GC33941 structure
    GC33941Dihydrochelerythrine (12,13-Dihydrochelerythrine)
    CAS: 6880-91-7
    纯度: >98.00%

    An alkaloid with diverse biological activities

  • GC33949 structure
    GC339494-Chlorosalicylic acid
    CAS: 5106-98-9
    纯度: >98.00%

    4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) was used in sensitive spectrofluorometric determination of terbium in mixed rare earths and preparation of poly(4-chlorosalicylic acid-formaldehyde) via condensation with formaldehyde. 4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.