GlpBio

Fungal

Fungal(真菌)

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品(356)

  • GC33957 structure
    GC33957Dehydroacetic acid (Biocide 470F)
    CAS: 520-45-6
    纯度: >98.00%

    Dehydroacetic acid (Biocide 470F, Methylacetopyronone) is an organic compound, used mostly as a fungicide and bactericide.

  • GC33958 structure
    GC33958Hexetidine (NSC-17764)
    CAS: 141-94-6
    纯度: >99.00% / >98.00%

    Hexetidine is an anti-bacterial and anti-fungal agent with local anesthetic, astringent, deodorant and antiplaque activity.

  • GC33965 structure
    GC33965Dihydrosanguinarine (13,14-Dihydrosanguinarine)
    CAS: 3606-45-9
    纯度: >98.00%

    A metabolite of sanguinarine with diverse biological activities

  • GC33976 structure
    GC339764',7-Dimethoxyisoflavone (Dimethoxydaidzein)
    CAS: 1157-39-7
    纯度: >95.00%

    4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.

  • GC33991 structure
    GC33991Hydroxyphenyllactic acid
    CAS: 306-23-0
    纯度: >98.50% / >98.00%

    Hydroxyphenyllactic acid是一种酪氨酸代谢物。

  • GC33996 structure
    GC33996Fosravuconazole (BMS-379224)
    CAS: 351227-64-0

    Fosravuconazole (BMS-379224) (BMS-379224) 是 Ravuconazole 的前药，是一种具有口服活性的广谱抗真菌剂。

  • GC34583 structure
    GC34583Faltan
    CAS: 133-07-3
    纯度: >98.50%

    Faltan是一种二甲酰亚胺杀真菌剂，广泛用于葡萄树和一些蔬菜作物，对人支气管上皮细胞有毒性。

  • GC34587 structure
    GC34587Fluopyram
    CAS: 658066-35-4

    Fluopyram是一种琥珀酸脱氢酶(succinatedehydrogenase)抑制剂，为有效的杀真菌剂，能够抑制F.virguliforme的生长，平均EC50值为3.35µg/mL。

  • GC34658 structure
    GC34658Mancozeb
    CAS: 8018-01-7

    Mancozeb是一种乙烯双二硫代氨基甲酸酯杀菌剂。

  • GC34773 structure
    GC34773Sakuranetin
    CAS: 2957-21-3
    纯度: >99.50%

    A flavonoid with diverse biological activities

  • GC34839 structure
    GC34839Thiophanate-Methyl
    CAS: 23564-05-8
    纯度: >99.50%

    Thiophanate-Methyl是一种内吸性杀菌剂。

  • GC34845 structure
    GC34845Trifloxystrobin
    CAS: 141517-21-7
    纯度: >99.50%

    A fungicide

  • GC34946 structure
    GC34946(-​)​-Maackiain
    CAS: 2035-15-6
    纯度: >98.50%

    Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.

  • GC34950 structure
    GC34950(-)-Ketoconazole
    CAS: 65277-42-1
    纯度: >99.50%

    A triazole antifungal agent

  • GC35068 structure
    GC350681-Monomyristin
    CAS: 589-68-4
    纯度: >98.00%

    A monoacylglycerol

  • GC35153 structure
    GC351535,7,3',4'-Tetramethoxyflavone
    CAS: 855-97-0
    纯度: >98.00%

    5,7,3',4'-Tetramethoxyflavone 是从 M. exotica 中分离得到的一种多甲氧基黄酮，具有多种生物活性，包括抗真菌、抗疟疾、抗分支杆菌和抗炎活性。5,7,3',4'-Tetramethoxyflavone 可通过靶向 β-catenin 发挥软骨保护作用。

  • GC35196 structure
    GC351967-Prenyloxycoumarin
    CAS: 10387-50-5
    纯度: >98.00%

    7-Prenyloxycoumarin (7-O-Prenylumbelliferone)是Annulohypoxylon ilanense 内生真菌的次生代谢物。

  • GC35232 structure
    GC35232Acetyllovastatin
    CAS: 81189-92-6
    纯度: >98.50%

    Acetyllovastatin 是一种 Lovastatin 的乙酸盐，对乙酰胆碱酯酶有中度抑制作用，IC50 为 79 μg/mL。Lovastatin 具有抗真菌活性，并抑制许多转化细胞系的增殖。

  • GC35300 structure
    GC35300Aloin(mixture of A&B)
    CAS: 8015-61-0
    纯度: >95.00%

    An anthroquinone with diverse biological activities

  • GC35306 structure
    GC35306α-Mangostin
    CAS: 6147-11-1
    纯度: >99.50% / >98.00%

    α-Mangostin是一种在 Garcinia mangostana 果皮中提取的天然氧杂蒽酮类化合物，具有广泛的生物活性。

  • GC35612 structure
    GC35612Carvacrol
    CAS: 499-75-2
    纯度: >99.50%

    Carvacrol 是一种具有口服活性的单萜酚。

  • GC35725 structure
    GC35725Coniferin
    CAS: 531-29-3
    纯度: >98.00%

    A phenylpropanoid glycoside with diverse biological activities

  • GC35726 structure
    GC35726Coniferyl alcohol
    CAS: 458-35-5
    纯度: >98.00%

    A monolignol

  • GC35732 structure
    GC35732Corypalmine
    CAS: 27313-86-6
    纯度: >98.50%

    Corypalmine ((R)-(+)-Corypalmine), an alkaloid isolated from Stephania cepharantha, is an inhibitor of prolyl endopeptidase/oligopeptidase (PREP/POP) with IC50 of 128.0 μM.