GlpBio

Fungal

Fungal(真菌)

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品(356)

  • GC36018 structure
    GC36018Exalamide
    CAS: 53370-90-4
    纯度: >99.50%

    Exalamide是一种抗真菌剂。

  • GC36057 structure
    GC36057Fluconazole mesylate
    CAS: 159532-41-9

    An antifungal agent

  • GC36059 structure
    GC36059Flumorph
    CAS: 211867-47-9
    纯度: >99.50%

    Flumorph(SYP-L190)是羧酸酰胺杀菌剂（CAA）。

  • GC36276 structure
    GC36276Hydroxy Itraconazole D8
    CAS: 1217516-26-1
    纯度: >99.50%

    Hydroxy Itraconazole D8(R-63373 D8)是Hydroxy Itraconazole氘代化合物标准品。

  • GC36384 structure
    GC36384Kanzonol C
    CAS: 151135-82-9
    纯度: >98.00%

    Kanzonol C 是从Dorstenia barteri (Moraceae) 提取到的一种黄酮类化合物，有治疗细菌和真菌感染的潜能。

  • GC36822 structure
    GC36822Oteseconazole
    CAS: 1340593-59-0
    纯度: >99.50%

    Oteseconazole (VT-1161) 是一种有效、可口服的抗真菌剂，有效结合并抑制白色念球菌的 CYP51 (Kd，<39 nM)，但对人 CYP51 无明显作用。

  • GC36950 structure
    GC36950Posaconazole-D5
    CAS: 1217785-83-5

    An internal standard for the quantification of posaconazole

  • GC37061 structure
    GC37061Quilseconazole
    CAS: 1340593-70-5

    Quilseconazole (VT-1129) 是一种有效、可口服的真菌 Cyp51 (fungal Cyp51) 抑制剂，能够与隐球菌的 Cyp51 紧密结合，但对人 Cyp51 的抑制作用很弱。

  • GC38164 structure
    GC38164Multifungin
    CAS: 3679-64-9
    纯度: >99.50%

    Salifungin (Multifungin, Bromosalicylchloranilide) is an antifungal and may cause allergic contact dermatitis in some individuals.

  • GC38246 structure
    GC38246Undecanoic acid
    CAS: 112-37-8
    纯度: >99.50%

    An eleven carbon SFA

  • GC38428 structure
    GC38428Hecogenin
    CAS: 467-55-0
    纯度: >99.90% / >99.00%

    A steroid sapogenin with diverse biological activities

  • GC38430 structure
    GC38430Hyperoside
    CAS: 482-36-0
    纯度: >99.50% / >98.00%

    Hyperoside（金丝桃苷）是一种NF-κB抑制剂，来源于金丝桃。Hyperoside具有抗肿瘤、抗真菌、抗炎、抗病毒和抗氧化活。

  • GC38681 structure
    GC38681Cedrol
    CAS: 77-53-2
    纯度: >98.00%

    A sesquiterpene alcohol

  • GC38685 structure
    GC38685Geraniol
    CAS: 106-24-1
    纯度: >99.00%

    A terpene alcohol with diverse biological activities

  • GC38725 structure
    GC38725(S,S)-Valifenalate
    CAS: 283159-94-4
    纯度: >98.00%

    (S,S)-Valifenalate ((S,S)-IR5885) 是一种酰胺酸杀菌剂，它被用来抑制卵菌纲的各种真菌。(S,S)-Valifenalate ((S,S)-IR5885) 干扰细胞壁合成，从而影响受控制病原体的生长阶段，无论是在孢子上还是在菌丝体上。

  • GC38908 structure
    GC38908E1210
    CAS: 936339-60-5
    纯度: >98.00%

    Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity.

  • GC38951 structure
    GC38951Thymol iodide
    CAS: 552-22-7

    Thymol iodide 是 Thymol 的碘化物。Thymol iodide 可替代碘仿。Thymol iodide 是 Thymol (一种源自百里香油的酚) 的碘衍生物，主要用作温和的杀菌剂和抗真菌剂。

  • GC38958 structure
    GC38958Sorbic acid
    CAS: 110-44-1
    纯度: >99.50%

    Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division).

  • GC38979 structure
    GC38979Vincetoxicoside B
    CAS: 22007-72-3
    纯度: >98.00%

    Vincetoxicoside B 从 Polygonum paleaceum Wall 中分离出的，具有抗真菌活性。

  • GC39001 structure
    GC39001Kakuol
    CAS: 18607-90-4
    纯度: >99.50%

    Kakuol 是一种从 Asarum sieboldii 根茎中分离得到的天然化合物，具有抗真菌活性。

  • GC39027 structure
    GC39027Lawsone
    CAS: 83-72-7

    Lawsone (Hennotannic acid, 2-hydroxy-1,4-naphthoquinone) is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).

  • GC39098 structure
    GC39098Tetrahydroepiberberine
    CAS: 38853-67-7

    An alkaloid with diverse biological activities

  • GC39116 structure
    GC39116Xanthoxylin
    CAS: 90-24-4
    纯度: >99.50%

    Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin.

  • GC39123 structure
    GC39123Lapachol
    CAS: 84-79-7
    纯度: >98.00%

    A naphthoquinone with diverse biological activities