GlpBio

Fungal

Fungal(真菌)

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品(356)

  • GC39347 structure
    GC39347Benzimidazole
    CAS: 51-17-2

    Benzimidazole 是一种杂环芳香族有机化合物，是药物化学中重要的药效基团。Benzimidazole 衍生物具有抗癌、抗病毒、抗菌、抗真菌、抗寄生虫、抗炎、质子泵抑制剂、抗凝血等多种生物活性。

  • GC39358 structure
    GC39358Chlorobutanol
    CAS: 57-15-8
    纯度: >98.00%

    Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran|, trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic with antibacterial and antifungal properties.

  • GC39371 structure
    GC39371Demethoxyencecalin
    CAS: 19013-07-1
    纯度: >95.00%

    Demethoxyencecalin 是从一种从向日葵中提取的色烯，具有抗真菌 (antifungal) 活性。

  • GC39408 structure
    GC39408Neticonazole
    CAS: 130726-68-0
    纯度: >99.00%

    Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity.

  • GC39409 structure
    GC39409Neticonazole hydrochloride
    CAS: 130773-02-3
    纯度: >99.50%

    Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.

  • GC39589 structure
    GC395895-Dehydroepisterol
    CAS: 23582-83-4

    5-Dehydroepisterol 是一种甾醇衍生物，是甾体生物合成的中间体 (intermediate)。5-Dehydroepisterol 可以由 C-5 甾醇去饱和酶形成，并通过 7-脱氢胆固醇还原酶转化为 24-亚甲基胆固醇。5-Dehydroepisterol 具有抗真菌 (anti-fungal) 活性。

  • GC39601 structure
    GC39601Chlormidazole hydrochloride
    CAS: 74298-63-8
    纯度: >98.00%

    Chlormidazole hydrochloride 是一种抗真菌剂 ( antifungal agent)，对多种真菌和部分革兰氏阳性球菌有抑制活性。Chlormidazole hydrochloride 可用于指甲和皮肤的真菌和细菌感染，包括指间和甲周真菌。

  • GC39687 structure
    GC396873,5-Dimethoxybenzoic acid
    CAS: 1132-21-4

    3,5-Dimethoxybenzoic acid 可从 Melia azedarach L. 叶子中分离得到，具有抗真菌活性，是有机合成的中间体。

  • GC39711 structure
    GC39711Fosetyl-aluminum
    CAS: 39148-24-8

    Fosetyl-aluminum (Fosetyl-Al) 是许多杀菌剂中抗霜霉病的活性成分。Fosetyl-aluminum 被用于控制农业和园艺作物上由疫霉引起的许多疾病。

  • GC39839 structure
    GC39839S.pombe lumazine synthase-IN-1
    CAS: 331726-35-3
    纯度: >98.00%

    S.pombe lumazine synthase-IN-1 是 lumazine 合酶的抑制剂，对粟酒裂殖酵母和结核分枝杆菌的 lumazine 合酶的 Ki 值分别为 243 μM 和 9.6 μM。

  • GC40261 structure
    GC40261Germacrene D
    CAS: 23986-74-5
    纯度: >95.00% / >90.00%

    A precursor in sesquiterpene biosynthesis

  • GC40669 structure
    GC40669Nerol
    CAS: 106-25-2
    纯度: >98.50%

    A monoterpene

  • GC41343 structure
    GC41343Nerolidol
    CAS: 7212-44-4
    纯度: >98.00%

    A sesquiterpene with diverse biological activities

  • GC41370 structure
    GC41370Magnoflorine
    CAS: 2141-09-5
    纯度: >98.00%

    An alkaloid

  • GC41466 structure
    GC41466Reveromycin A
    CAS: 134615-37-5
    纯度: >99.00%

    A spiroketal antibiotic with antiproliferative activity

  • GC41501 structure
    GC41501α-Terpinene
    CAS: 99-86-5
    纯度: >96.00%

    A terpenoid with diverse biological activities

  • GC41503 structure
    GC41503γ-Terpinene
    CAS: 99-85-4
    纯度: >96.50% / >95.00%

    A monoterpene with diverse biological activities

  • GC42484 structure
    GC424845,6-dihydroxy Indole
    CAS: 3131-52-0
    纯度: >95.00% / >99.00%

    An intermediate in melanogenesis

  • GC42492 structure
    GC424925-bromo-5-nitro-1,3-Dioxane
    CAS: 30007-47-7
    纯度: >98.00%

    An antimicrobial agent

  • GC43358 structure
    GC43358Cytochalasin A
    CAS: 14110-64-6
    纯度: >98.00%

    Inhibitor of actin polymerization

  • GC43439 structure
    GC43439Diallyl Trisulfide
    CAS: 2050-87-5
    纯度: >98.00%

    Diallyl Trisulfide是一种从大蒜中提取的有机硫化合物。

  • GC43882 structure
    GC43882Hygrolidin
    CAS: 83329-73-1
    纯度: >95.00%

    A macrocyclic lactone

  • GC43911 structure
    GC43911Isavuconazonium (sulfate)
    CAS: 946075-13-4
    纯度: >95.00%

    A prodrug form of isavuconazole

  • GC44485 structure
    GC44485Ochratoxin C
    CAS: 4865-85-4
    纯度: >98.00%

    Ochratoxin C（OTC）是赭曲霉毒素的衍生物，是一种真菌毒素，属于Ochratoxin A的乙酯衍生物。