Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity.
Neticonazole treatment significantly reduces the Bcl-2/Bax ratio, leading to the restoration of the apoptosis level in xenograft tumors, which echoes the observation of inhibited tumor growth in neticonazole-treated IDB mice.[4]
[1] Amrita Datta, et al. Sci Rep. 2018 May 25;8(1):8161. [2] Sumiko Ishizaki, et al. Med Mycol J. 2019;60(4):91-94. [3] Lei Gu, et al. Invest New Drugs. 2020 Apr;38(2):221-228.
















