(2S)-6-Prenylnaringenin is a prenylated flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities.1,2 It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 in HEK293 cells and high-voltage-activated calcium currents in differentiated NG 108-15 cells in whole-cell patch-clamp assays (IC50s = 0.928 and 2.005 ?M, respectively).1 (2S)-6-Prenylnaringenin reduces the activity of aldose reductase 2 (ALR2; IC50 = 6.2 ?M for the recombinant human enzyme).2 It reduces mechanical allodynia in a mouse model of sodium hydrosulfide-induced somatic pain when administered at a dose of 10 pmol/paw.1
1.Sekiguchi, F., Fujita, T., Deguchi, T., et al.Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in miceNeuropharmacology138232-244(2018) 2.Shim, S.H., Kim, Y., Lee, J.Y., et al.Aldose reductase inhibitory activity of the compounds from the seed of Psoralea corylifoliaJ. Korean Soc. Appl. Biol. Chem.52(5)568–572(2009)