Diallyl Trisulfide is an organosulfur compound derived from garlic [1]. Diallyl Trisulfide increases reactive oxygen species (ROS) in cancer cells, leading to oxidative stress and consequently cell cycle arrest (particularly at the G2/M phase) [2]. Diallyl Trisulfide inhibits tumor migration, invasion, and angiogenesis, and may also modulate signaling pathways such as MAPK, STAT3, PKC-δ, and Nrf2/Akt [3]. Diallyl Trisulfide is primarily used to treat gastric, breast, and prostate cancers [4].
In human primary colorectal cancer cells, Diallyl Trisulfide (0-40μM; 24h) reduces cell viability [5]. In colo 205 cells, Diallyl Trisulfide (0-50μM; 24h) reduces cell viability [6].
In diabetic mice ischemia model, Diallyl Trisulfide (500μg/kg; ip; 14d) significantly improved the more severe tissue damage and vascular dysfunction in diabetic mice during ischemic injury [7]. In CT-26 cells xenograft mice model, treatment with Diallyl Trisulfide (10mg/kg, 50mg/kg; ip; 4 weeks) resulted in a decrease in tumor volume and weight [8].
References:
[1]. Liang D, Wu H, Wong M W, et al. Diallyl trisulfide is a fast H2S donor, but diallyl disulfide is a slow one: the reaction pathways and intermediates of glutathione with polysulfides[J]. Organic letters, 2015, 17(17): 4196-4199.
[2]. Na H K, Kim E H, Choi M A, et al. Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1[J]. Biochemical pharmacology, 2012, 84(10): 1241-1250.
[3]. Guo X, Su B. Diallyl Trisulfide Intervention in Redox Homeostasis and Its Multitarget Antitumor Effects[J]. Journal of Agricultural and Food Chemistry, 2025.
[4]. Lu L, Gao Z, Song J, et al. The potential of diallyl trisulfide for cancer prevention and treatment, with mechanism insights[J]. Frontiers in Cell and Developmental Biology, 2024, 12: 1450836.
[5]. Yu C S, Huang A C, Lai K C, et al. Diallyl trisulfide induces apoptosis in human primary colorectal cancer cells[J]. Oncology reports, 2012, 28(3): 949-954.
[6]. Lai K C, Hsu S C, Kuo C L, et al. Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase‐2,‐7, and‐9 expressions[J]. Environmental toxicology, 2013, 28(9): 479-488.
[7]. Yang H B, Liu H M, Yan J C, et al. Effect of diallyl trisulfide on ischemic tissue injury and revascularization in a diabetic mouse model[J]. Journal of Cardiovascular Pharmacology, 2018, 71(6): 367-374.
[8]. Wu P P, Liu K C, Huang W W, et al. Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo[J]. Phytomedicine, 2011, 18(8-9): 672-676.
Diallyl Trisulfide是一种从大蒜中提取的有机硫化合物 [1]。Diallyl Trisulfide会增加癌细胞中的活性氧（ROS），导致氧化应激，从而导致细胞周期停滞（尤其是在G2/M期） [2]。Diallyl Trisulfide可抑制肿瘤迁移、侵袭和血管生成，并可能调节MAPK、STAT3、PKC-δ和Nrf2/Akt等信号通路 [3]。二烯丙基三硫化物主要用于治疗胃癌、乳腺癌和前列腺癌 [4]。
在人类原发性结直肠癌细胞中，Diallyl Trisulfide（0-40μM；24h）会降低细胞活力 [5]。在Colo 205细胞中，Diallyl Trisulfide（0-50μM；24h）会降低细胞活力 [6]。
在糖尿病小鼠缺血模型中，Diallyl Trisulfide（500μg/kg；ip；14d）显著改善了糖尿病小鼠缺血性损伤过程中较严重的组织损伤和血管功能障碍 [7]。在CT-26细胞异种移植小鼠模型中，Diallyl Trisulfide（10mg/kg，50mg/kg；ip；4周）治疗导致肿瘤体积和重量减小 [8]。