GlpBio

Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Reactive Oxygen Species 相关产品(453)

  • GC64933 structure
    GC64933Catalase from bovine liver(2000-5000u/mg)
    CAS: 9001-05-2
    纯度: BA-2000-5000u/mg

    Catalase是重要的抗氧化酶,在清除ROS。在维持氧化还原状态的平衡方面发挥着重要作用。Catalase与肿瘤的发生,发展关系密切。有潜力用于肿瘤的预防研究。

  • GA10800 structure
    GA10800H-Cys(Me)-OH
    CAS: 1187-84-4

    H-Cys(Me)-OH 是一种天然产物，在由甲硫氨酸亚砜还原酶 A (MSRA) 介导的催化抗氧化系统中充当底物，具有抗氧化、神经保护和抗肥胖活性。

  • GC10042 structure
    GC10042Vitamin E
    CAS: 59-02-9
    纯度: >99.00% / >98.00%

    脂溶性维生素

  • GC10282 structure
    GC10282Piperlongumine
    CAS: 20069-09-4
    纯度: >99.00% / >98.00%

    Piperlongumine是从 Piper longum L. 中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。

  • GC10331 structure
    GC10331Ebselen
    CAS: 60940-34-3
    纯度: 99.97%

    Ebselen一种具有谷胱甘肽过氧化物酶样活性的硒代有机化合物，是一种抗炎和抗氧化剂。Ebselen是肌醇单磷酸酶（IMPase）的抑制剂，IC 50 为1.5μM。

  • GC10981 structure
    GC10981Disodium (R)-2-Hydroxyglutarate
    CAS: 103404-90-6
    纯度: >98.00% / >95.00%

    An α-hydroxy acid

  • GC11443 structure
    GC11443Allylthiourea
    CAS: 109-57-9
    纯度: >98.00%

    烯丙基硫脲是一种选择性抑制氨氧化的代谢抑制剂。

  • GC11513 structure
    GC11513Zofenopril calcium
    CAS: 81938-43-4
    纯度: >99.50%

    A prodrug form of zofenoprilat

  • GC11660 structure
    GC11660Nitisinone
    CAS: 104206-65-7
    纯度: >99.50%

    An HPPD inhibitor

  • GC11702 structure
    GC11702DL-Carnitine HCl
    CAS: 461-05-2
    纯度: >98.00%

    DL-Carnitine HCl 存在两种异构体，称为 D 和 L。

  • GC11707 structure
    GC11707L-Ascorbyl 6-palmitate
    CAS: 137-66-6
    纯度: >99.00%

    A lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities

  • GC11770 structure
    GC11770Ketone Ester
    CAS: 1208313-97-6
    纯度: >99.50%

    A ketone ester with anti-obesity and anticonvulsant activities

  • GC11786 structure
    GC11786Acetylcysteine
    CAS: 616-91-1
    纯度: >99.00%

    乙酰半胱氨酸是半胱氨酸的 N-乙酰基衍生物。

  • GC12070 structure
    GC12070Ascorbic acid (Standard)
    CAS: 50-81-7
    纯度: >99.50% / >98.00%

    An electron donor

  • GC12203 structure
    GC12203L-Glutathione Reduced
    CAS: 70-18-8
    纯度: >99.00% / >97.00%

    Nucleophilic co-substrate to glutathione transferases and electron donor to glutathione peroxidases

  • GC12517 structure
    GC12517Sasapyrine
    CAS: 552-94-3
    纯度: >98.00%

    An NSAID and a prodrug form of salicylic acid

  • GC12520 structure
    GC12520Diphenyleneiodonium chloride
    CAS: 4673-26-1
    纯度: >99.50%

    二苯碘铵 (DPI) 氯化物 (DPIC) 作为 NADH/NADPH 氧化酶抑制剂，对 Mtb 和 S. aureus 具有有效的抗菌活性。

  • GC13345 structure
    GC13345NXY-059
    CAS: 168021-79-2
    纯度: >98.00%

    NXY-059具有神经保护活性的自由基捕获剂，NXY-059可中和自由基来减少氧化损伤，同时通过保护血脑屏障完整性以减轻神经炎症。

  • GC13502 structure
    GC13502Cysteamine HCl
    CAS: 156-57-0
    纯度: >98.00%

    A radioprotective aminothiol

  • GC13616 structure
    GC13616Sodium ascorbate
    CAS: 134-03-2
    纯度: >98.00% / >99.00%

    Sodium ascorbate是一种内源性抗氧化剂，通过参与体内的羟化反应，促进细胞间质形成、辅助合成皮质激素，并通过促进叶酸还原和铁离子吸收来影响血细胞成熟，同时具有抗组胺和阻止亚硝胺生成的作用。

  • GC13795 structure
    GC13795Isobavachalcone
    CAS: 20784-50-3
    纯度: >98.00%

    A chalcone and flavonoid with diverse biological activities

  • GC14049 structure
    GC14049(-)-Epigallocatechin gallate (EGCG)
    CAS: 989-51-5
    纯度: >99.50% / >99.00% / >98.00%

    (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。

  • GC14282 structure
    GC14282AKBA (3-acetyl-11-keto-β-Boswellic Acid)
    CAS: 67416-61-9
    纯度: >98.00%

    AKBA (3-acetyl-11-keto-β-Boswellic Acid)是一种五环三萜酸，能够有效地非竞争性地抑制5-脂氧合酶（5-lipoxygenase, 5-LOX），具有抗炎、抗肿瘤、神经保护等多种生物活性。

  • GC14586 structure
    GC14586Efaproxiral Sodium
    CAS: 170787-99-2
    纯度: >99.50%

    An allosteric hemoglobin modifier