Reactive Oxygen Species
Reactive Oxygen Species(活性氧)
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Reactive Oxygen Species 相关产品(453)
- GC31350AstaxanthinCAS: 472-61-7纯度: >98.00%
Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.
- GC31353Glutathione oxidized (L-Glutathione oxidized)CAS: 27025-41-8纯度: >98.50% / >99.00%
Glutathione oxidized (L-Glutathione oxidized)，是抗氧化剂L-谷胱甘肽的氧化形式，作为一种信号分子，可触发抗氧化基因的激活。
- GC31377Tofogliflozin hydrate (CSG-452 hydrate)CAS: 1201913-82-7纯度: >98.50% / >98.00%
A potent inhibitor of SGLT2
- GC31511Sinapinic acid (Sinapic acid)CAS: 530-59-6纯度: >99.50%
A phenylpropanoid hydroxycinnamic acid with diverse biological activities
- GC31709Succinobucol (AGI-1067)CAS: 216167-82-7纯度: >99.50% / >98.00%
A probucol derivative with diverse biological activities
- GC31794Methyl vanillateCAS: 3943-74-6纯度: >99.00%
Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
- GC32439Ferulic acid sodium (Sodium ferulate)CAS: 24276-84-4纯度: >99.00%
A phenol with diverse biological activities
- GC32681GSK2795039CAS: 1415925-18-6纯度: >99.50% / >98.00%
GSK2795039是一种强效NADPH氧化酶2（NOX2）抑制剂，IC 50 值为0.18μM。
- GC33444Octahydrocurcumin (Hexahydrobisdemethoxycurcumin)CAS: 36062-07-4纯度: >98.00%
An active metabolite of curcumin with diverse biological activities
- GC33606D-(+)-Glucono-1,5-lactone (Gluconic acid lactone)CAS: 90-80-2纯度: >99.00%
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.
- GC33632Veratric acid (3,4-Dimethoxybenzoic acid)CAS: 93-07-2
Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
- GC33779Cysteamine (β-Mercaptoethylamine)CAS: 60-23-1纯度: >95.00%
2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.
- GC339923,4-Dimethoxycinnamic acid (O-Methylferulic acid)CAS: 2316-26-9纯度: >99.50%
3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
- GC34115Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone)CAS: 319-89-1
A redox-active hydroxyquinone
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC31350 | Astaxanthin | 472-61-7 | >98.00% | |
Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. | ||||
| GC31353 | Glutathione oxidized (L-Glutathione oxidized) | 27025-41-8 | >98.50% / >99.00% | |
Glutathione oxidized (L-Glutathione oxidized)，是抗氧化剂L-谷胱甘肽的氧化形式，作为一种信号分子，可触发抗氧化基因的激活。 | ||||
| GC31377 | Tofogliflozin hydrate (CSG-452 hydrate) | 1201913-82-7 | >98.50% / >98.00% | |
A potent inhibitor of SGLT2 | ||||
| GC31511 | Sinapinic acid (Sinapic acid) | 530-59-6 | >99.50% | |
A phenylpropanoid hydroxycinnamic acid with diverse biological activities | ||||
| GC31671 | Emeramide (BDTH2) | 351994-94-0 | >98.00% | |
Emeramide (BDTH2)是一种脂溶性重金属螯合剂和抗氧化剂。 | ||||
| GC31709 | Succinobucol (AGI-1067) | 216167-82-7 | >99.50% / >98.00% | |
A probucol derivative with diverse biological activities | ||||
| GC31794 | Methyl vanillate | 3943-74-6 | >99.00% | |
Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro. | ||||
| GC32170 | Methyl gallate (Gallincin) | 99-24-1 | >99.50% | |
A phenol with diverse biological activities | ||||
| GC32216 | Squalene (Super Squalene) | 111-02-4 | >98.00% | |
A biosynthetic precursor to steroids | ||||
| GC32439 | Ferulic acid sodium (Sodium ferulate) | 24276-84-4 | >99.00% | |
A phenol with diverse biological activities | ||||
| GC32681 | GSK2795039 | 1415925-18-6 | >99.50% / >98.00% | |
GSK2795039是一种强效NADPH氧化酶2（NOX2）抑制剂，IC 50 值为0.18μM。 | ||||
| GC32887 | Efaproxiral (RSR13) | 131179-95-8 | >99.50% | |
An allosteric hemoglobin modifier | ||||
| GC32946 | PK11007 | 38275-34-2 | >99.00% | |
PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death. | ||||
| GC32965 | Ethoxyquin | 91-53-2 | >98.00% | |
An antioxidant used in animal feed | ||||
| GC32999 | Glucoraphanin | 21414-41-5 | >98.00% | |
A natural compound with protective effects | ||||
| GC33134 | Bufotalin | 471-95-4 | 98.46% | |
Bufotalin是一种天然的强心类固醇，来源于蟾蜍分泌物。 | ||||
| GC33444 | Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) | 36062-07-4 | >98.00% | |
An active metabolite of curcumin with diverse biological activities | ||||
| GC33479 | Hexaconazole ((-)-Hexaconazol) | 79983-71-4 | - | |
A triazole fungicide | ||||
| GC33606 | D-(+)-Glucono-1,5-lactone (Gluconic acid lactone) | 90-80-2 | >99.00% | |
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity. | ||||
| GC33632 | Veratric acid (3,4-Dimethoxybenzoic acid) | 93-07-2 | - | |
Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation. | ||||
| GC33779 | Cysteamine (β-Mercaptoethylamine) | 60-23-1 | >95.00% | |
2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine. | ||||
| GC33827 | Uric acid | 69-93-2 | >99.00% / >98.00% | |
Uric Acid (2,6,8-Trioxypurine, 2,6,8-Trihydroxypurine, 2,6,8-Trioxopurine), a normal component of urine, is a product of the metabolic breakdown of purine nucleotides. | ||||
| GC33992 | 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) | 2316-26-9 | >99.50% | |
3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM. | ||||
| GC34115 | Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone) | 319-89-1 | - | |
A redox-active hydroxyquinone | ||||