Reactive Oxygen Species
Reactive Oxygen Species(活性氧)
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Reactive Oxygen Species 相关产品(453)
- GC15168Urolithin ACAS: 1143-70-0纯度: >98.00%
Urolithin A是由鞣花酸和鞣花单宁代谢产生的一种活性成分，可作为酪氨酸酶（IC 50 值为71.44±10.07µmol/L）和单胺氧化酶A（IC 50 值为29.41±9.01µmol/L）的强效抑制剂。
- GC15548Ellagic acidCAS: 476-66-4纯度: >99.50%
Ellagic acid是一种天然存在的多酚二内酯，广泛存在于多种水果和坚果中，可有效抑制CK2（IC 50 =40nM）和SHP2（K i =20nM）的活性。
- GC16921Bromhexine HClCAS: 611-75-6纯度: >99.00%
Bromhexine HCl 是一种有效且特异性的 TMPRSS2 蛋白酶抑制剂，IC50 为 0.75 μM。
- GC18325Ferrichrome (iron-free)CAS: 34787-28-5纯度: >98.00%
Ferrichrome (iron-free)是一种来自 Ustilago sphaerogena 的铁离子载体，可作为亚铁螯合酶的铁源。
- GC18583D-α-Hydroxyglutaric AcidCAS: 13095-47-1纯度: >98.00%
D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K i = 10.87mM）。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC14847 | Psoralidin | 18642-23-4 | >98.00% | |
A furanocoumarin with anti-cancer activity | ||||
| GC15168 | Urolithin A | 1143-70-0 | >98.00% | |
Urolithin A是由鞣花酸和鞣花单宁代谢产生的一种活性成分，可作为酪氨酸酶（IC 50 值为71.44±10.07µmol/L）和单胺氧化酶A（IC 50 值为29.41±9.01µmol/L）的强效抑制剂。 | ||||
| GC15548 | Ellagic acid | 476-66-4 | >99.50% | |
Ellagic acid是一种天然存在的多酚二内酯，广泛存在于多种水果和坚果中，可有效抑制CK2（IC 50 =40nM）和SHP2（K i =20nM）的活性。 | ||||
| GC15550 | Lacidipine | 103890-78-4 | >99.50% | |
An L-type calcium channel blocker | ||||
| GC15949 | Benfotiamine | 22457-89-2 | >99.00% | |
A lipid-soluble form of vitamin B 1 | ||||
| GC16306 | Dapsone | 80-08-0 | >99.00% | |
An anti-inflammatory, antimalarial, and antibacterial compound | ||||
| GC16517 | Eugenol | 97-53-0 | >98.00% | |
丁香酚是一种存在于丁香中的精油，具有抗菌、驱虫和抗氧化活性。 | ||||
| GC16795 | DCA | 2156-56-1 | >99.00% / >98.00% | |
DCA 是癌细胞中的代谢调节剂'；具有抗癌活性的线粒体。 DCA 抑制 PDHK，导致肿瘤微环境中的乳酸减少。 DCA 增加活性氧 (ROS) 生成并促进癌细胞凋亡。 DCA 也可作为 NKCC 抑制剂。 | ||||
| GC16889 | Nisoldipine | 63675-72-9 | >99.00% | |
A calcium channel inhibitor | ||||
| GC16921 | Bromhexine HCl | 611-75-6 | >99.00% | |
Bromhexine HCl 是一种有效且特异性的 TMPRSS2 蛋白酶抑制剂，IC50 为 0.75 μM。 | ||||
| GC17574 | BAPTA | 85233-19-8 | >98.00% | |
BAPTA是一种高钙选择性螯合剂，用于分析钙在不同细胞功能中的作用。 | ||||
| GC18190 | Lecanoric Acid | 480-56-8 | >95.00% | |
An antioxidant | ||||
| GC18235 | 1-O-Hexadecyl-sn-glycerol | 506-03-6 | >98.00% | |
An alkyl glyceryl ether | ||||
| GC18325 | Ferrichrome (iron-free) | 34787-28-5 | >98.00% | |
Ferrichrome (iron-free)是一种来自 Ustilago sphaerogena 的铁离子载体，可作为亚铁螯合酶的铁源。 | ||||
| GC18488 | Cyclo(L-Leu-L-Trp) | 15136-34-2 | - | |
A diketopiperazine metabolite | ||||
| GC18517 | Diapocynin | 29799-22-2 | - | |
An inhibitor of NADPH-oxidase | ||||
| GC18583 | D-α-Hydroxyglutaric Acid | 13095-47-1 | >98.00% | |
D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K i = 10.87mM）。 | ||||
| GC18645 | Piperitenone | 491-09-8 | - | |
A monoterpene | ||||
| GC18673 | OBA-09 | 856095-68-6 | >99.50% | |
A neuroprotective agent | ||||
| GC18776 | 6α-hydroxy Cholesterol | 41083-73-2 | >95.00% | |
An oxysterol | ||||
| GC18788 | Graphislactone A | 52179-44-9 | - | |
An antioxidant | ||||
| GC18789 | Lobaric Acid | 522-53-2 | - | |
A lichen metabolite with diverse biological activities | ||||
| GC18858 | 4-hydroxy Alternariol | 959417-21-1 | - | |
A metabolite of alternariol | ||||
| GC18922 | Camalexin | 135531-86-1 | >99.50% | |
Camalexin是拟南芥中一种源自色氨酸且具有抗菌活性的生物碱类植物抗毒素。 | ||||