GlpBio

Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Reactive Oxygen Species 相关产品(453)

  • GC34116 structure
    GC34116Hexahydrocurcumin
    CAS: 36062-05-2
    纯度: >99.50%

    A natural product and an active metabolite of curcumin

  • GC34617 structure
    GC34617HO-1-IN-1
    CAS: 1093058-52-6
    纯度: >98.00%

    HO-1-IN-1是一种血红素氧合酶-1（HO-1）抑制剂，其IC 50 为 0.25μM [1 。

  • GC34618 structure
    GC34618HO-1-IN-1 hydrochloride
    CAS: 1092851-70-1
    纯度: >99.00%

    HO-1-IN-1 hydrochloride是一种血红素氧合酶-1（HO-1）抑制剂，其IC 50 为 0.25μM [1 。

  • GC34694 structure
    GC34694Octyl gallate
    CAS: 1034-01-1
    纯度: >99.50%

    Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.

  • GC34758 structure
    GC34758Reynoutrin
    CAS: 549-32-6

    A flavonoid glycoside with diverse biological activities

  • GC34894 structure
    GC34894CycLuc1
    CAS: 1247879-16-8
    纯度: >98.00%

    CycLuc1是一种合成的、具有血脑屏障通透性的荧光素酶底物，最大发射波长 λ max =604nm。

  • GC35037 structure
    GC350371,3-Dicaffeoylquinic acid
    CAS: 19870-46-3
    纯度: >98.50%

    1,3-Dicaffeoylquinic acid能抑制HIV-1整合酶的3'端加工、末端连接以及解体过程，IC 50 值分别为0.35、0.56和0.84μg/ml。

  • GC35095 structure
    GC350952-Phospho-L-ascorbic acid trisodium salt
    CAS: 66170-10-3
    纯度: >97.00% / >99.00%

    Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.

  • GC35306 structure
    GC35306α-Mangostin
    CAS: 6147-11-1
    纯度: >99.50% / >98.00%

    α-Mangostin是一种在 Garcinia mangostana 果皮中提取的天然氧杂蒽酮类化合物，具有广泛的生物活性。

  • GC35497 structure
    GC35497Berberine chloride hydrate
    CAS: 68030-18-2
    纯度: >99.50% / >99.00%

    As isoquinoline alkaloid with diverse biological activities

  • GC35529 structure
    GC35529Bixin
    CAS: 6983-79-5

    Bixin (BX) 红木素从 Bixa orellana 的种子中分离，一种类胡萝卜素，具有抗炎，抗肿瘤和抗氧化活性。Bixin (BX) 红木素通过抑制纤维化，炎症和活性氧 (ROS) 的产生来改善心脏功能障碍。

  • GC35996 structure
    GC35996Epiberberine chloride
    CAS: 889665-86-5
    纯度: >99.50%

    An alkaloid with diverse biological activities

  • GC36176 structure
    GC36176Gomisin D
    CAS: 60546-10-3

    A lignan with diverse biological activities

  • GC36262 structure
    GC36262Huangjiangsu A
    CAS: 1026020-27-8

    Huangjiangsu A 是从 D. villosa 中分离的原三角藻皂苷元。Huangjiangsu A 抗 H2O2-诱导的细胞毒性和 ROS 生成，具有肝保护作用。

  • GC36443 structure
    GC36443Levomefolic acid
    CAS: 31690-09-2
    纯度: >98.50%

    Levomefolic acid是一种具有口服活性且可通过血脑屏障的叶酸生物活性形式。

  • GC36492 structure
    GC36492Luciferase
    CAS: 9014-00-0

    Luciferase是一种能够催化生物发光反应的酶。

  • GC37531 structure
    GC37531Riboflavin Tetrabutyrate
    CAS: 752-56-7
    纯度: >98.00%

    Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.

  • GC37661 structure
    GC37661Sodium formononetin-3'-sulfonate
    CAS: 949021-68-5
    纯度: >99.50%

    Sodium formononetin-3'-sulfonate (Sul-F)是formononetin的水溶性衍生物。

  • GC37700 structure
    GC37700Succinyl phosphonate trisodium salt
    CAS: 864167-45-3
    纯度: >98.00% / >99.50%

    Succinyl phosphonate trisodium salt (SP) 琥珀酰膦酸三钠盐是 α-酮戊二酸脱氢酶 (KGDHC ) 抑制剂，可有效抑制肌肉，细菌，脑和人成纤维细胞中的 KGDHC。Succinyl phosphonate trisodium salt (SP) 抑制 2-氧代戊二酸脱氢酶 (OGDH)，以细胞特异性代谢依赖性方式损害癌细胞的活力。Succinyl phosphonate trisodium salt (SP) 抑制谷氨酸诱导的谷氨酸刺激的海马神经元中的 ROS 产生。

  • GC38149 structure
    GC38149Ecabet sodium
    CAS: 86408-72-2
    纯度: >98.00%

    An antiulcerative and gastroprotective agent

  • GC38316 structure
    GC38316(-)-Limonene
    CAS: 5989-54-8
    纯度: >95.00%

    A monoterpene with diverse biological activities

  • GC38680 structure
    GC38680Citronellol
    CAS: 106-22-9
    纯度: >99.00%

    A monoterpene

  • GC38803 structure
    GC38803J14
    CAS: 1043854-13-2
    纯度: >99.00%

    J14 是一种可逆 sulfiredoxin 抑制剂，IC50 为 8.1 μM。J14 通过抑制 sulfiredoxin 诱导氧化应激 (导致细胞内 ROS 积累)，从而导致细胞毒性和癌细胞死亡。

  • GC38973 structure
    GC38973Osmundacetone
    CAS: 37079-84-8

    Osmundacetone 是从 Osmundae Rhizoma 中分离出的一种天然产物。