Reactive Oxygen Species
Reactive Oxygen Species(活性氧)
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Reactive Oxygen Species 相关产品(453)
- GC38978MoslosooflavoneCAS: 3570-62-5纯度: >99.00%
Moslosooflavoneone 是从雪莲中分离出来的类黄酮。 Moslofoflavone 具有抗缺氧和抗炎活性。
- GC39109IsodeoxyelephantopinCAS: 38927-54-7
Isodeoxyelephantopin 是一种倍半萜烯内酯，可从Elephantopus scaber 中分离得到。Isodeoxyelephantopin 可诱导活性氧的生成，抑制NF-κB 的激活。Isodeoxyelephantopin 还能调节LncRNA 的表达，有抗乳腺癌的作用。
- GC39239Rifamycin SCAS: 13553-79-2纯度: >98.00%
Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
- GC39600Iron sucroseCAS: 8047-67-4纯度: >98.00%
Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.
- GC39747(E/Z)-GSK5182CAS: 2699724-40-6纯度: >98.50%
(E/Z)-GSK5182 是 (E)-GSK5182 和 (Z)-GSK5182 的消旋体。GSK5182 是一种高效选择性，具有口服活性的 ERRγ 反向激动剂，其 IC50 值为 79 nM。GSK5182 还能增加肝癌细胞中 reactive oxyen species (ROS) 的产生。
- GC40736trans-trismethoxy ResveratrolCAS: 22255-22-7纯度: >99.50%
A stilbene with diverse biological activities
- GC40921Orsellinic AcidCAS: 480-64-8纯度: >97.00%
A fungal metabolite with antioxidant and neuroprotective activities
- GC40928Trimethylamine N-oxideCAS: 1184-78-7纯度: >95.00%
A metabolite of choline, phosphatidylcholine, and L-carnitine
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38978 | Moslosooflavone | 3570-62-5 | >99.00% | |
Moslosooflavoneone 是从雪莲中分离出来的类黄酮。 Moslofoflavone 具有抗缺氧和抗炎活性。 | ||||
| GC39100 | Rutaevin | 33237-37-5 | - | |
Rutaevin 从 Euodia rutaecarpa 中分离。 Rutaevin 能够抑制 Raw 264.7 巨噬细胞中 LPS 诱导的 NO 的产生。 | ||||
| GC39109 | Isodeoxyelephantopin | 38927-54-7 | - | |
Isodeoxyelephantopin 是一种倍半萜烯内酯，可从Elephantopus scaber 中分离得到。Isodeoxyelephantopin 可诱导活性氧的生成，抑制NF-κB 的激活。Isodeoxyelephantopin 还能调节LncRNA 的表达，有抗乳腺癌的作用。 | ||||
| GC39239 | Rifamycin S | 13553-79-2 | >98.00% | |
Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. | ||||
| GC39271 | (±)-Naringenin | 67604-48-2 | >98.50% | |
A citrus- derived flavonoid | ||||
| GC39512 | Tempo | 2564-83-2 | - | |
Tempo 是一种经典的一氧化氮自由基，也 是一种线粒体 ROS 的选择性清除剂，可在催化循环中使超氧化物歧化。Tempo 可诱导 DNA 链断裂，并可用作将伯醇氧化为醛的有机催化剂。Tempo 具有诱变和抗氧化作用。 | ||||
| GC39600 | Iron sucrose | 8047-67-4 | >98.00% | |
Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia. | ||||
| GC39747 | (E/Z)-GSK5182 | 2699724-40-6 | >98.50% | |
(E/Z)-GSK5182 是 (E)-GSK5182 和 (Z)-GSK5182 的消旋体。GSK5182 是一种高效选择性，具有口服活性的 ERRγ 反向激动剂，其 IC50 值为 79 nM。GSK5182 还能增加肝癌细胞中 reactive oxyen species (ROS) 的产生。 | ||||
| GC39756 | N-Acetyl-D-cysteine | 26117-28-2 | - | |
N-Acetyl-D-cysteine 具有抗氧化活性，通过与巯基反应清除 ROS，但不能进入谷胱甘肽代谢途径。 | ||||
| GC39760 | 5-Galloylquinic acid | 53584-43-3 | - | |
5-Galloylquinic acid 是绿茶中活性氧 (ROS) 的主要清除剂。 | ||||
| GC40006 | Pyranonigrin A | 773855-65-5 | >95.00% | |
A fungal metabolite with antioxidant activity | ||||
| GC40146 | 1-Oleoyl-2-Palmitoyl-rac-glycerol | 3331-34-8 | >95.00% | |
A diacylglycerol | ||||
| GC40298 | N-acetyl-5-Aminosalicylic Acid | 51-59-2 | >98.00% | |
A metabolite of 5-ASA and sulfasalazine | ||||
| GC40355 | (±)13-HpODE | 23017-93-8 | >95.00% | |
Hydroperoxide mixture derived from linoleic acid | ||||
| GC40477 | 4-Thiouracil | 591-28-6 | >98.00% | |
A photoreactive nucleobase analog | ||||
| GC40555 | Tiopronin | 1953-02-2 | >98.00% | |
Tiopronin is an antioxidant that has diverse biological activities. | ||||
| GC40557 | DMNQ | 6956-96-3 | >99.00% | |
Inducer of intracellular ROS generation | ||||
| GC40632 | CMS121 | 1353224-53-9 | >98.00% / >98.50% | |
CMS121是一种口服有效的乙酰辅酶A羧化酶1（ACC1）抑制剂。 | ||||
| GC40669 | Nerol | 106-25-2 | >98.50% | |
A monoterpene | ||||
| GC40736 | trans-trismethoxy Resveratrol | 22255-22-7 | >99.50% | |
A stilbene with diverse biological activities | ||||
| GC40809 | (+)-β-Citronellol | 1117-61-9 | >99.00% | |
A monoterpene | ||||
| GC40921 | Orsellinic Acid | 480-64-8 | >97.00% | |
A fungal metabolite with antioxidant and neuroprotective activities | ||||
| GC40922 | SRS11-92 | 1467047-25-1 | >98.00% | |
A ferroptosis inhibitor | ||||
| GC40928 | Trimethylamine N-oxide | 1184-78-7 | >95.00% | |
A metabolite of choline, phosphatidylcholine, and L-carnitine | ||||