Reactive Oxygen Species
Reactive Oxygen Species(活性氧)
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Reactive Oxygen Species 相关产品(453)
- GC41617(±)-α-TocopherolCAS: 10191-41-0纯度: >99.50% / >96.00%
A biologically active form of vitamin E
- GC41700(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazineCAS: 1000672-89-8纯度: >98.00%
A stilbene derivative with antioxidant and anticancer activities
- GC4186610-methyl-9-(phenoxycarbonyl) Acridinium (trifluoromethylsulfonate)CAS: 161006-14-0纯度: >95.00%
A chemiluminescent acridinium ester
- GC42079DCFH2-DA (2',7'-Dichlorofluorescein diacetate)CAS: 2044-85-1纯度: >98.00%
DCFH2-DA (2',7'-Dichlorofluorescein diacetate)是一种具有细胞膜渗透性的通用氧化应激指示剂，可用于检测活性氧（ROS）、一氧化氮（·NO）及评估总体氧化应激水平，广泛应用于细胞氧化还原过程的监测。
- GC422513-Bromotyrosine (trifluoroacetate salt)CAS: 2320428-62-2纯度: >95.00%
A product of protein oxidation
- GC424014-hydroperoxy CyclophosphamideCAS: 39800-16-3纯度: >98.00% / >95.00%
4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。
- GC426278-Hydroxyguanine (hydrochloride)CAS: 1246818-54-1纯度: >90.00%
Product of oxidative damage to DNA or RNA
- GC426429,10-Anthracenediyl-bis(methylene)dimalonic AcidCAS: 307554-62-7纯度: >97.00%
9,10-Anthracenediyl-bis(methylene)dimalonic Acid是一种水溶性蒽衍生物，通常作为单线态氧探针应用。9,10-Anthracenediyl-bis(methylene)dimalonic Acid可以被单线态氧光漂白为其相应的内过氧化物，导致在大约380-400nm处的吸光度随时间减少。
- GC43297Coenzyme Q2CAS: 606-06-4纯度: >95.00%
A biosynthetic precursor to CoQ 10 and an inhibitor of mitochondrial complex I
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC40979 | Maresin 1 | 1268720-28-0 | >95.00% | |
A specialized pro-resolving mediator | ||||
| GC41152 | Norgestrel | 6533-00-2 | >99.50% | |
A synthetic progestin | ||||
| GC41262 | (±)-α-CMBHC | 7083-09-2 | >98.00% | |
A metabolite of (±)-α-tocopherol | ||||
| GC41290 | EMPO | 61856-99-3 | >98.00% | |
A free radical spin trap | ||||
| GC41397 | BMPO | 387334-31-8 | >98.00% | |
BMPO是一种环状硝酮自旋捕集剂，它是一种水溶性白色固体，比其他自旋捕集剂更容易提纯BMPO。 | ||||
| GC41502 | β-Myrcene | 123-35-3 | >95.00% / >98.00% | |
A terpene with antioxidative properties | ||||
| GC41617 | (±)-α-Tocopherol | 10191-41-0 | >99.50% / >96.00% | |
A biologically active form of vitamin E | ||||
| GC41623 | β-Elemonic Acid | 28282-25-9 | >98.00% | |
A triterpene with anticancer activity | ||||
| GC41700 | (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine | 1000672-89-8 | >98.00% | |
A stilbene derivative with antioxidant and anticancer activities | ||||
| GC41721 | (R)-α-Lipoic Acid | 1200-22-2 | >99.50% | |
A cyclic disulfide antioxidant | ||||
| GC41837 | 1,3,7-Trimethyluric Acid | 5415-44-1 | >98.00% | |
A metabolite of caffeine | ||||
| GC41866 | 10-methyl-9-(phenoxycarbonyl) Acridinium (trifluoromethylsulfonate) | 161006-14-0 | >95.00% | |
A chemiluminescent acridinium ester | ||||
| GC41868 | 10-Nitrooleate | 875685-46-4 | >98.00% | |
A novel endogenous lipid signalling molecule | ||||
| GC42079 | DCFH2-DA (2',7'-Dichlorofluorescein diacetate) | 2044-85-1 | >98.00% | |
DCFH2-DA (2',7'-Dichlorofluorescein diacetate)是一种具有细胞膜渗透性的通用氧化应激指示剂，可用于检测活性氧（ROS）、一氧化氮（·NO）及评估总体氧化应激水平，广泛应用于细胞氧化还原过程的监测。 | ||||
| GC42251 | 3-Bromotyrosine (trifluoroacetate salt) | 2320428-62-2 | >95.00% | |
A product of protein oxidation | ||||
| GC42338 | 4-Aminobenzoic Acid hydrazide | 5351-17-7 | >99.00% | |
An MPO inhibitor | ||||
| GC42351 | 4-carboxy TEMPO | 37149-18-1 | >97.00% | |
A spin label | ||||
| GC42401 | 4-hydroperoxy Cyclophosphamide | 39800-16-3 | >98.00% / >95.00% | |
4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。 | ||||
| GC42627 | 8-Hydroxyguanine (hydrochloride) | 1246818-54-1 | >90.00% | |
Product of oxidative damage to DNA or RNA | ||||
| GC42642 | 9,10-Anthracenediyl-bis(methylene)dimalonic Acid | 307554-62-7 | >97.00% | |
9,10-Anthracenediyl-bis(methylene)dimalonic Acid是一种水溶性蒽衍生物，通常作为单线态氧探针应用。9,10-Anthracenediyl-bis(methylene)dimalonic Acid可以被单线态氧光漂白为其相应的内过氧化物，导致在大约380-400nm处的吸光度随时间减少。 | ||||
| GC42649 | 9-Nitrooleate | 875685-44-2 | >98.00% | |
A novel endogenous lipid signalling molecule | ||||
| GC42825 | APF | 359010-70-1 | >98.00% / >95.00% | |
APF是一种新型ROS指示剂，可选择性、剂量依赖性地与溶液和细胞中某些活性氧结合后产生荧光，其最大激发/发射波长分别为490/515nm。 | ||||
| GC43139 | Capsanthin | 465-42-9 | >75.00% | |
A carotenoid with diverse biological activities | ||||
| GC43297 | Coenzyme Q2 | 606-06-4 | >95.00% | |
A biosynthetic precursor to CoQ 10 and an inhibitor of mitochondrial complex I | ||||