Gomisin D is a lignan that has been found in S. chinensis and has diverse biological activities, including enzyme inhibitory and antioxidant properties.1,2,3 It inhibits acetylcholinesterase (AChE) with an IC50 value of 7.84 ?M.1 Gomisin D scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals (IC50s = 24.5 and 203 ?M, respectively).3 It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A3 by 89.9 and 83.1%, respectively, when used at a concentration of 100 ?M.2 It is selective for UGT1A1 and UGT1A3 over other UGT isoforms at 100 ?M.
1.Hung, T.M., Na, M., Min, B.S., et al.Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensisArch. Pharm. Res.30(6)685-690(2007) 2.Song, J.-H., Cui, L., An, L.-B., et al.Inhibition of UDP-glucuronosyltransferases (UGTs) activity by constituents of Schisandra chinensisPhytother. Res.29(10)1658-1664(2015) 3.Poornima, B., Kumar, D.A., Siva, B., et al.Advanced glycation end-products inhibitors isolated from Schisandra grandifloraNat. Prod. Res.30(4)493-496(2016)