AA26-8 is a pan-serine hydrolase inhibitor.1 It inhibits acylaminoacyl-peptide hydrolase (APEH), platelet-activating factor acetylhydrolase 2 (PAF-AH2), α/β hydrolase domain-containing protein 11 (ABHD11), lysophospholipase 1 (LYPLA1), fatty acid amide hydrolase (FAAH), and neutral cholesterol ester hydrolase 1 (NCEH1) when used at a concentration of 1 ?M. AA26-8 (10 ?M) also inhibits the interaction of the α/β hydrolase Dwarf14 (D14) and a negative regulator of its signaling, D53, induced by the plant growth regulator GR24 in a yeast two-hybrid assay.2
1.Adibekian, A., Martin, B.R., Wang, C., et al.Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitorsNat. Chem. Biol.7(7)469-478(2011) 2.Nakamura, H., Hirabayashi, K., Miyakawa, T., et al.Triazole ureas covalently bind to strigolactone receptor and antagonize strigolactone responsesMol. Plant12(1)44-58(2019)