Docosahexaenoic Acid ethyl ester-d5

Docosahexaenoic Acid ethyl ester-d₅ (DHA ethyl ester-d₅) contains five deuterium atoms. It is intended for use as an internal standard for the quantification of DHA ethyl ester by GC- or LC-mass spectrometry. DHA ethyl ester is the stabilized ethyl ester form of the ω-3 22:6 fatty acid. Dietary intake of DHA ethyl ester enhances maze-learning ability in old mice.¹ In rats, dietary DHA ethyl ester increases plasma and erythrocyte membrane DHA levels without altering the content of the ω-6 arachidonic acid.² Dietary DHA ethyl ester increases fatty acid oxidation enzymes in rats and, in humans with peroxisomal disorders, improves vision, liver function, muscle tone, and social contact.³,⁴ The ω-3 fatty acid eicosapentaenoic acid (EPA) competitively inhibits the metabolism of arachidonic acid by cyclooxygenase enzymes, suggesting that DHA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism.⁵

1.Lim, S.Y., and Suzuki, H.Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old miceJournal of Nutrition1301629-1632(2000) 2.Valenzuela, A., Valenzuela, V., Sanhueza, J., et al.Effects of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in ratsAnnuals of Nutrition and Metabolism4949-53(2005) 3.Hong, D.D., Takahashi, Y., Kushiro, M., et al.Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the ratBiochimica et Biophysica Acta163529-36(2003) 4.Martinez, M., VÁzquez, E., GarcÍa-Silva, M.T., et al.Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disordersAmerican Journal of Clinical Nutrition71376S-385S(2000) 5.Wada, M., DeLong, C.J., Hong, Y.H., et al.Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and productsJ. Biol. Chem.282(31)22254-22266(2007)