Adrenocorticotropic hormone (ACTH) (18-39) is a C-terminal peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response.1 It is produced via processing of ACTH in the intermediate lobe of the pituitary gland.1,2 ACTH (18-39) increases cumulative food intake in fasted, but not fed, rats when administered intracerebroventricularly at a dose of 2.5 nmol/animal.2
1.Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al.Non-corticotropic ACTH peptides modulate nerve development and regenerationRev. Neurosci.4(4)321-363(1993) 2.Al-Barazanji, K.A., Miller, J.E., Rice, S.Q.J., et al.C-terminal fragments of ACTH stimulate feeding in fasted ratsHorm. Metab. Res.33(8)480-485(2001)