5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME .
(±)5(6)-DiHET lactone
目录号: GC40437纯度: >98.00%同义词: (±)5,6DiHETrE lactone
A lactone form of (±)5(6)-DiHET
Cas No.: 213126-92-2
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 25μg | ¥1,417.00 | 现货 | 1 | |
| 50μg | ¥2,680.00 | 现货 | 1 | |
| 100μg | ¥4,990.00 | 现货 | 1 | |
| 250μg | ¥11,073.00 | 现货 | 1 |
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Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
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产品描述 Description
产品文档 Product Documents
Purity:>98.00%Appearance:A solution in ethanol
化学性质Chemical Properties
CAS 号
213126-92-2
同义词
(±)5,6DiHETrE lactone
SMILES
O=C(O1)CCC[C@H]1[C@H](O)C/C=C\C/C=C\C/C=C\CCCCC
分子式
C20H32O3
分子量
320.5 g/mol
溶解性
DMF: >50 mg/ml (per Rao Maddipati),DMSO: >50 mg/ml (per Rao Maddipati),Ethanol: >50 mg/ml (per Rao Maddipati),PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol