Xanthyletin is a coumarin that has been found in Z. avicennae and has diverse biological activities, including antifungal, antioxidant, and anticancer properties.1,2,3 It is active against the fungi R. solani, F. graminearum, and P. oryzae (IC50s = 49.1, 117.2, and 31.6 mg/L, respectively).1 Xanthyletin (50 mg/L) is also active against F. oxysporum, A. solani, and S. sclerotiorum. It reduces LPS-induced production of nitric oxide (NO) in BV-2 microglial cells with an IC50 value of 5.4 ?M.2 Xanthyletin inhibits proliferation of A549 lung, MCF-7 breast, and PC3 prostate cancer cells (IC50s = 80.1, 19.3, and 97.2 ?g/ml, respectively).3
1.Xiong, Y., Huang, G., Yao, Z., et al.Screening effective antifungal substances from the bark and leaves of Zanthoxylum avicennae by the bioactivity-guided isolation methodMolecules24(23)E4207(2019) 2.Chan, Y.-Y., Li, C.-H., Shen, Y.-C., et al.Anti-inflammatory principles from the stem and root barks of Citrus medicaChem. Pharm. Bull. (Tokyo)58(1)61-65(2010) 3.Tahsin, T., Wansi, J.D., Al-Groshi, A., et al.Cytotoxic properties of the stem bark of Citrus reticulata blanco (Rutaceae)Phytother. Res.31(8)1215-1219(2017)