GlpBio

Fungal

Fungal(真菌)

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品(356)

  • GC16707 structure
    GC16707Isavuconazole
    CAS: 241479-67-4
    纯度: >98.00%

    A broad-spectrum triazole antifungal agent

  • GC16757 structure
    GC16757Sertaconazole nitrate
    CAS: 99592-39-9
    纯度: >98.00%

    A broad spectrum antifungal agent

  • GC16804 structure
    GC16804Clotrimazole
    CAS: 23593-75-1
    纯度: >99.50% / >99.00%

    An imidazole antifungal

  • GC17006 structure
    GC17006Latrunculin B
    CAS: 76343-94-7
    纯度: >97.00% / >96.00%

    Latrunculin B 是一种可穿透细胞的肌动蛋白聚合抑制剂，在体外和体内可通过与单体 G-actin形成 1:1 复合物来抑制肌动蛋白聚合。Latrunculin B 调节肺静脉电生理特性并减弱拉伸诱导的心律失常发生。

  • GC17066 structure
    GC17066Terbinafine
    CAS: 91161-71-6
    纯度: >98.50%

    Terbinafine（TDT 067）是一种新型烯丙胺类抗真菌剂，也是一种有效的非竞争性角鲨烯环氧化酶抑制剂（K i 值为30 nM），可以选择性地抑制角鲨烯环氧化酶，导致麦角甾醇的减少，从而干扰膜功能和细胞生长。

  • GC17087 structure
    GC17087Dyclonine HCl
    CAS: 536-43-6
    纯度: >98.00%

    A topical anesthetic with diverse biological activities

  • GC17198 structure
    GC17198Cycloheximide
    CAS: 66-81-9
    纯度: >98.00%

    环己酰亚胺是一种抗生素，它在翻译水平上抑制蛋白质合成，仅对真核细胞的细胞质（80s）核糖体起作用。

  • GC17337 structure
    GC17337Ketoconazole
    CAS: 65277-42-1
    纯度: >99.50%

    A triazole antifungal agent

  • GC17493 structure
    GC17493Miconazole Nitrate
    CAS: 22832-87-7
    纯度: >99.50%

    An antifungal azole

  • GC17507 structure
    GC17507Micafungin sodium
    CAS: 208538-73-2
    纯度: >98.00%

    Micafungin sodium是一种棘白菌素类抗真菌药，能够抑制白色念珠菌中的1，3-β-D-葡聚糖合成。Micafungin sodium是Micafungin（货号：GC32244）的钠盐形式，Micafungin能够用于治疗多种真菌感染，包括念珠菌病和曲霉病。

  • GC17528 structure
    GC17528Oxiconazole (nitrate)
    CAS: 64211-46-7
    纯度: >98.00%

    An antifungal agent

  • GC17540 structure
    GC17540Chlorquinaldol
    CAS: 72-80-0
    纯度: >98.00%

    An antimicrobial monohydroxyquinoline

  • GC17554 structure
    GC17554Efinaconazole
    CAS: 164650-44-6
    纯度: >98.00%

    A triazole antifungal agent

  • GC17614 structure
    GC17614Posaconazole
    CAS: 171228-49-2
    纯度: >99.50%

    An antifungal agent

  • GC17752 structure
    GC17752Bifonazole
    CAS: 60628-96-8
    纯度: >99.50%

    A topically-active antifungal

  • GC17883 structure
    GC17883Fluconazole hydrate
    CAS: 155347-36-7

    An antifungal agent

  • GC18131 structure
    GC18131Aminothiazole
    CAS: 96-50-4
    纯度: >98.00%

    氨基噻唑（2-氨基噻唑）是一种典型的杂环胺，是合成生物活性分子的前体，包括硫化剂、杀菌剂、杀菌剂、抗生素、染料和化学反应促进剂。

  • GC18297 structure
    GC18297Bafilomycin B1
    CAS: 88899-56-3
    纯度: >97.00%

    A fungal metabolite with diverse biological activities

  • GC18406 structure
    GC18406Filipin Complex
    CAS: 11078-21-0
    纯度: >97.00% / >97.50% / >98.00%

    菲律宾配合物是一种中性多烯，具有抗真菌活性。

  • GC18414 structure
    GC18414Tyrothricin
    CAS: 1404-88-2

    A polypeptide antibiotic mixture

  • GC18644 structure
    GC18644Sordarin (sodium salt)
    CAS: 463356-00-5
    纯度: >98.00%

    An inhibitor of fungal protein synthesis

  • GC18922 structure
    GC18922Camalexin
    CAS: 135531-86-1
    纯度: >99.50%

    Camalexin是拟南芥中一种源自色氨酸且具有抗菌活性的生物碱类植物抗毒素。

  • GC25181 structure
    GC25181Butenafine
    CAS: 101828-21-1

    Butenafine is a synthetic benzylamine antifungal agent.

  • GC25182 structure
    GC25182Butoconazole
    CAS: 64872-76-0

    Butoconazole is an imidazole antifungal used in gynecology.