Fraxinol is a coumarin originally isolated from Ash tree bark.1 It inhibits growth of GLC-4 small cell lung carcinoma and COLO 320 colorectal cancer cells (IC50s = 193 and 165 μM, respectively).2 Fraxinol potentiates barbiturate-induced sleep in rats and rabbits.3
1.Spath, E., and Jerzmanowska-Sienkiewiczowa, Z.Natural coumarins. XXV. Fraxinol, a new constituent of the bark of the ashBerichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen70B698-702(1937) 2.Kolodziej, H., Kayser, O., Woerdenbag, H.J., et al.Structure-cytotoxicity relationships of a series of natural and semi-synthetic simple coumarins as assessed in two human tumour cell linesZ. Naturforsch. C52(3-4)240-244(1997) 3.Khadzhai, Y.I.Effect of coumarin, flavonoid, and khellin derivatives on the soporific effect of barbituratesFarmakologiya i Toksikologiya (Kiev)746-48(1972)