RGD (Arg-Gly-Asp) Peptides is a tripeptide that can bind to integrins, effectively induce cell adhesion, locate a specific cell line and produce a specific cellular response[1]. RGD (Arg-Gly-Asp) Peptides regulates cell adhesion, migration and signal transduction by competitively binding to the integrin ligand binding domain[2]. RGD (Arg-Gly-Asp) Peptides can be chemically modified (such as cyclization, conjugation) to expand its application in drug delivery, imaging diagnosis and other fields[3, 4]. RGD (Arg-Gly-Asp) Peptides are widely used in cancer targeted therapy, tissue engineering and cardiovascular disease research[5].
References:
[1] Sheu J R, Lin C H, Peng H C, et al. Triflavin, an Arg-Gly-Asp-containing peptide, inhibits the adhesion of tumor cells to matrix proteins via binding to multiple integrin receptors expressed on human hepatoma cells[J]. Proceedings of the Society for Experimental Biology and Medicine, 1996, 213(1): 71-79.
[2] Takagi J. Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrins[J]. Biochemical Society Transactions, 2004, 32(3): 403-406.
[3] Battistini L, Bugatti K, Sartori A, et al. RGD peptide‐drug conjugates as effective dual targeting platforms: recent advances[J]. European Journal of Organic Chemistry, 2021, 2021(17): 2506-2528.
[4] Lee S, Xie J, Chen X. Peptides and peptide hormones for molecular imaging and disease diagnosis[J]. Chemical reviews, 2010, 110(5): 3087-3111.
[5] Zhao J, Santino F, Giacomini D, et al. Integrin-targeting peptides for the design of functional cell-responsive biomaterials[J]. Biomedicines, 2020, 8(9): 307.
RGD (Arg-Gly-Asp) Peptides是一种三肽，能够与整合素结合，有效引起细胞黏着，定位某种特定细胞系并产生特定的细胞反应[1]。RGD (Arg-Gly-Asp) Peptides通过竞争性结合整合素配体结合域，调控细胞黏附、迁移和信号转导[2]。RGD (Arg-Gly-Asp) Peptides能够通过化学修饰（如环化、偶联）扩展其在药物递送、成像诊断等领域的应用[3, 4]。RGD (Arg-Gly-Asp) Peptides广泛应用于癌症靶向治疗、组织工程和心血管疾病研究等领域[5]。