GlpBio

C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt)

目录号: GC46993纯度: >99.00%同义词: C18 GM2-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM2, Monosialoganglioside GM2-d3, N-Stearoyl Monosialoganglioside GM2-d3
A neuropeptide with diverse biological activities
C18 Ganglioside GM2-d3 (d18:1/18:0-d3) (ammonium salt)
Cas No.: N/A
规格价格库存数量操作
250 μg¥8,395.00现货
1
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文献被引

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产品描述 Description

C18 Ganglioside GM2-d3 is intended for use as an internal standard for the quantification of ganglioside GM2 by GC- or LC-MS. C18 Ganglioside GM2 is a monosialylated ganglioside found in the mammalian brain where it is localized to the cell membrane.1 It accumulates in Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively.2 Ganglioside GM2 disrupts the function of immune cells and, when used at a concentration of 25 µM, increases migration and invasion of SK-RC-45 cells with no effect on proliferation.3 [Matreya, LLC. Catalog No. 2051]

1.Schnaar, R.L.Gangliosides of the vertebrate nervous systemJ. Mol. Biol.428(16)3325-3336(2016) 2.Baek, R.C., Martin, D.R., Cox, N.R., et al.Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff diseaseLipids44(3)197-205(2009) 3.Kundu, M., Mahata, B., Banerjee, A., et al.Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathwayBiochim. Biophys. Acta.1863(7 Pt A)1472-1489(2016)

产品文档 Product Documents

Purity:>99.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
N/A
同义词
C18 GM2-d3, N-omega-CD3-Octadecanoyl monosialoganglioside GM2, Monosialoganglioside GM2-d3, N-Stearoyl Monosialoganglioside GM2-d3
SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@]2([H])[C@@H]([C@@]([C@H]([C@H](O2)CO)O[C@]3([H])O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)([H])O[C@]4(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@@H]([C@H](O)CO)O)O4)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O.[NH4+]
分子式
C67H117D3N3O26.NH4
分子量
1404.7 g/mol
溶解性
Chloroform:Methanol:Water (2:1:0.1): Soluble
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol