P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
P450 相关产品(439)
- GC1878313,14-dihydro-15-keto Prostaglandin E1CAS: 5094-14-4纯度: >98.00%
An inactive metabolite of PGE 1
- GC18791Prostaglandin H1CAS: 52589-22-7纯度: >95.00%
The precursor to all 1-series prostaglandins and thromboxanes
- GC20027(±)5(6)-DiHET MaxSpec® StandardCAS: 213382-49-1纯度: >95.00%
5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.
- GC30424(-)-Cephaeline dihydrochloride (NSC 32944)CAS: 5853-29-2纯度: >99.50%
(-)-Cephaeline dihydrochloride (NSC 32944) 是一种选择性 CYP2D6 抑制剂，IC50 为 121 μM.
- GC30459Senecionine (Senecionan-11,16-dione, 12-hydroxy-)CAS: 130-01-8纯度: >99.00%
A pyrrolizidine alkaloid with hepatotoxic properties
- GC30479Dihydromethysticin ((+)-Dihydromethysticin)CAS: 19902-91-1纯度: >98.50%
A kavalactone with diverse biological activities
- GC30681RevexeprideCAS: 219984-49-3
Revexepride是一种高度选择性的5-HT4receptor激动剂，也是潜在的CYP3A4enzyme诱导剂，可用于治疗胃食管返流疾病。
- GC30705Veledimex S enantiomer (INXN-1001 S enantiome)CAS: 1093131-03-3纯度: >99.50%
Veledimex S 对映体 (INXN-1001 S enantiomer) 是 veledimex 的 S 对映体。 Veledimex 是专有基因治疗启动子系统的口服激活剂配体，也是 CYP3A4/5 的中度抑制剂和底物。
- GC31141Antihistamine-1CAS: 1186430-60-3
Antihistamine-1是能够渗透血脑屏障的H1-抗组胺药(Ki=6.9nM),它也是CYP2D6和hERG通道的抑制剂，其IC50值分别为5.4和0.8μM。
- GC31422MCH-1 antagonist 1CAS: 1039825-68-7
MCH-1antagonist1是一种有效的黑色素浓缩激素1(MCH-1)拮抗剂，Ki值为2.6nM。MCH-1antagonist1还抑制CYP3A4，IC50为10μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC18622 | (2'S)-Nicotine-1-oxide | 2820-55-5 | - | |
A nicotine metabolite | ||||
| GC18654 | 8-hydroxy Loxapine | 61443-77-4 | - | |
A loxapine metabolite | ||||
| GC18698 | CAY10665 | 1235543-17-5 | - | |
A stable bioisostere of the antiarrhythmic 17,18-EET | ||||
| GC18706 | SR 9186 | 1361414-26-7 | - | |
A selective inhibitor of CYP3A4 | ||||
| GC18783 | 13,14-dihydro-15-keto Prostaglandin E1 | 5094-14-4 | >98.00% | |
An inactive metabolite of PGE 1 | ||||
| GC18791 | Prostaglandin H1 | 52589-22-7 | >95.00% | |
The precursor to all 1-series prostaglandins and thromboxanes | ||||
| GC18817 | 3β-hydroxy-5-Cholestenoic Acid | 6561-58-6 | - | |
An active cholesterol metabolite | ||||
| GC18879 | CAY10662 | 1184844-74-3 | - | |
A urea derivative of 17(18)-EpETE | ||||
| GC19301 | Pradefovir mesylate | 625095-61-6 | >99.50% | |
Pradefovir mesylate 是肝脏 CYP3A4 的良好底物。 | ||||
| GC19415 | DMU2105 | 1821143-79-6 | >98.00% | |
DMU2105 是一种有效且特异性的 CYP1B1 抑制剂，对 CYP1B1 和 CYP1A1 的 IC50 分别为 10 nM 和 742 nM。 | ||||
| GC19416 | DMU2139 | 1821143-80-9 | >98.00% | |
DMU2139是一种有效的CYP1B1抑制剂，IC 50 值为9nM。 | ||||
| GC19483 | MS-PPOH | 206052-02-0 | - | |
A potent, selective inhibitor of microsomal CYP450 epoxidase activity | ||||
| GC19691 | Pyrene | 129-00-0 | >99.50% | |
Pyrene 是由四个稠合苯环组成的多环芳烃 (PAH)。 | ||||
| GC20027 | (±)5(6)-DiHET MaxSpec® Standard | 213382-49-1 | >95.00% | |
5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases. | ||||
| GC20062 | trans-3'-Hydroxycotinine | 34834-67-8 | >98.00% | |
A metabolite of nicotine | ||||
| GC30424 | (-)-Cephaeline dihydrochloride (NSC 32944) | 5853-29-2 | >99.50% | |
(-)-Cephaeline dihydrochloride (NSC 32944) 是一种选择性 CYP2D6 抑制剂，IC50 为 121 μM. | ||||
| GC30459 | Senecionine (Senecionan-11,16-dione, 12-hydroxy-) | 130-01-8 | >99.00% | |
A pyrrolizidine alkaloid with hepatotoxic properties | ||||
| GC30479 | Dihydromethysticin ((+)-Dihydromethysticin) | 19902-91-1 | >98.50% | |
A kavalactone with diverse biological activities | ||||
| GC30681 | Revexepride | 219984-49-3 | - | |
Revexepride是一种高度选择性的5-HT4receptor激动剂，也是潜在的CYP3A4enzyme诱导剂，可用于治疗胃食管返流疾病。 | ||||
| GC30705 | Veledimex S enantiomer (INXN-1001 S enantiome) | 1093131-03-3 | >99.50% | |
Veledimex S 对映体 (INXN-1001 S enantiomer) 是 veledimex 的 S 对映体。 Veledimex 是专有基因治疗启动子系统的口服激活剂配体，也是 CYP3A4/5 的中度抑制剂和底物。 | ||||
| GC30966 | Olivetol | 500-66-3 | >99.50% | |
An Analytical Reference Standard | ||||
| GC30985 | Methysticin (DL-Methysticin) | 20697-20-5 | - | |
A natural kava lactone | ||||
| GC31141 | Antihistamine-1 | 1186430-60-3 | - | |
Antihistamine-1是能够渗透血脑屏障的H1-抗组胺药(Ki=6.9nM),它也是CYP2D6和hERG通道的抑制剂，其IC50值分别为5.4和0.8μM。 | ||||
| GC31422 | MCH-1 antagonist 1 | 1039825-68-7 | - | |
MCH-1antagonist1是一种有效的黑色素浓缩激素1(MCH-1)拮抗剂，Ki值为2.6nM。MCH-1antagonist1还抑制CYP3A4，IC50为10μM。 | ||||