FAAH
FAAH(脂肪酰胺水解酶)
Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.
FAAH 相关产品(36)
- GC15231Oleoyl Ethyl AmideCAS: 85075-82-7纯度: >98.00%
An endocannabinoid analog that inhibits FAAH and has analgesic activity
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11290 | TC-F 2 | 1304778-15-1 | - | |
TC-F 2 是脂肪酸酰胺水解酶 (FAAH) 的可逆非共价结合抑制剂，IC50 为 28 nM。 | ||||
| GC12693 | JZL 195 | 1210004-12-8 | >98.00% | |
JZL 195是一种具有高效选择性、不可逆的脂肪酸酰胺水解酶（FAAH）和单酰甘油脂肪酶（MAGL）双重抑制剂，IC 50 值分别为2nM和4nM。 | ||||
| GC14581 | JNJ-1661010 | 681136-29-8 | >98.50% | |
A selective FAAH inhibitor | ||||
| GC15077 | SA 47 | 792236-07-8 | >99.00% | |
SA 47 是一种选择性强效的脂肪酸酰胺水解酶 (FAAH) 和氨基甲酸酯抑制剂 。 | ||||
| GC15094 | LY2183240 | 874902-19-9 | >99.00% | |
A potent, competitive inhibitor of anandamide uptake | ||||
| GC15358 | PF 750 | 959151-50-9 | >98.00% | |
A selective, potent FAAH inhibitor | ||||
| GC15951 | URB597 | 546141-08-6 | >99.00% | |
An inhibitor of FAAH | ||||
| GC17855 | SA 57 | 1346169-63-8 | - | |
An inhibitor of FAAH, MAGL, and ABHD6 | ||||
| GC10133 | JNJ-42165279 | 1346528-50-4 | >99.50% | |
An irreversible FAAH inhibitor | ||||
| GC12031 | Monoacylglycerol Lipase Inhibitor 21 | 1643657-35-5 | - | |
A reversible blocker of 2-AG hydrolysis | ||||
| GC12546 | JP83 | 887264-44-0 | - | |
A potent, irreversible FAAH inhibitor | ||||
| GC13063 | N-Benzylpalmitamide | 74058-71-2 | >98.00% | |
A long-chain fatty acid amide | ||||
| GC13953 | Methyl α-Linolenyl Fluorophosphonate | - | - | |
A phospholipase inhibitor | ||||
| GC13963 | Oleyl Trifluoromethyl Ketone | 177987-23-4 | - | |
An analog of oleic acid | ||||
| GC15210 | PF-622 | 898235-65-9 | - | |
A selective, potent FAAH inhibitor | ||||
| GC15231 | Oleoyl Ethyl Amide | 85075-82-7 | >98.00% | |
An endocannabinoid analog that inhibits FAAH and has analgesic activity | ||||
| GC16033 | TAK 21d | 1143578-94-2 | - | |
TAK 21d (compound 21d) 是一种有效的、具有口服活性并能穿过血脑屏障脂肪酸酰胺水解酶 (FAAH) 的抑制剂，对 hFAAH 和 rFAAH 的 IC50 分别为 0.72 和 0.28 nM。 | ||||
| GC17159 | 4-(n-nonyl) Benzeneboronic Acid | 256383-45-6 | - | |
Potent inhibitor of FAAH | ||||
| GC17341 | Carprofen | 53716-49-7 | >99.50% | |
An NSAID used in animals | ||||
| GC18174 | BIA 10-2474 | 1233855-46-3 | >98.00% | |
An inhibitor of FAAH | ||||
| GC30366 | FAAH-IN-2 | 184475-71-6 | >99.40% | |
FAAH-IN-2是摘自专利WO/2008/100977A2中的FAAH抑制剂。 | ||||
| GC30751 | FAAH-IN-1 | 1242441-47-9 | - | |
FAAH-IN-1是脂肪酸酰胺水解酶(FAAH)抑制剂，对大鼠和人FAAH的IC50值分别为145nM和650nM。 | ||||
| GC31239 | SA72 | 934809-60-6 | - | |
SA72是高度选择性的脂肪酸酰胺水解酶(FAAH)抑制剂。 | ||||
| GC35068 | 1-Monomyristin | 589-68-4 | >98.00% | |
A monoacylglycerol | ||||