Metabolism(代谢)

Cat.No. 产品名称 Information

GC40226 Curcumin-d6

(1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

An internal standard for the quantification of curcumin

GC40220 Pravastatin-d3 (sodium salt) An internal standard for the quantification of pravastatin

GC40211 Ferrostatin-1 Diyne A ferroptosis inhibitor

GC40203 Cholesterol-d6

胆固醇-26,26,26,27,27,27-D6

An internal standard for the quantification of cholesterol

GC40201 7β-hydroxy Cholesterol-d7

7BETA-羟基胆固醇-25,26,26,26-27,27,27-D7

An internal standard for the quantification of 7β-hydroxy cholesterol

GC40193 UAMC-3203 A ferroptosis inhibitor

GC40191 Ibuprofen Carboxylic Acid

羧基布洛芬

A major metabolite of ibuprofen

GC40190 Febuxostat Acyl Glucuronide

非布司他杂质

A metabolite of febuxostat

GC40167 1,3-Dipalmitoyl-2-Docosahexaenoyl-rac-glycerol

1,3-Palmitin-2-Docoahexaenoin, 16:0/22:6/16:0-TG, TG(16:0/22:6/16:0)

A triacylglycerol

GC40145 (S)-Laudanosine

(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045

The (S) enantiomer of laudanosine

GC40144 Levofloxacin N-oxide

左氧氟沙星EP杂质C (Levofloxacin N-Oxide)

An inactive metabolite of levofloxacin

GC40143 Dihydrotetrabenazine

反式(2,3)-二氢丁苯那嗪

An active metabolite of tetrabenazine

GC40142 Lactosylceramides (bovine buttermilk)

乳糖苷

A sphingolipid

GC40132 ACTH (6-24) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

HFRWGKPVGKKRRPVKVYP

A peptide fragment of ACTH

GC40112 (±)-Climbazole-d4

甘宝素-D4溶液,100PPM,BAY-e 6975-d4

An internal standard for the quantification of climbazole

GC40094 all-trans Retinoic Acid-d5

atRA-d5, RA-d5, Vitamin A Acid-d5

An internal standard for the quantification of all-trans retinoic acid

GC40086 AZ 33 An inhibitor of LDHA

GC40041 Cholesteryl Lignocerate

24:0 CE, 24:0 Cholesterol ester

A cholesterol ester

GC40024 Altenusin

细格菌素,Alutenusin

A fungal metabolite with diverse biological activities

GC40018 Donepezil N-oxide

多奈哌齐N氧化物

An active metabolite of donepezil

GC40016 Ganglioside GM2 Mixture (sodium salt)

单唾液酸神经节苷脂GM2; GM2; Monosialoganglioside GM2

A mixture of ganglioside G_M2

GC40014 Steryl Glucosides A mixture of steryl glucosides

GC40007 Malformin A

Malformin A1

A cyclopentapeptide fungal metabolite with diverse biological activities

GC34353 LMPTP INHIBITOR 1 hydrochloride LMPTPINHIBITOR1(hydrochloride)是一种选择性的低分子量蛋白酪氨酸磷酸酶(LMPTP)抑制剂，能够抑制LMPTP-A的活性，IC50值为0.8μM。

GC34186 2-Aminobenzenesulfonamide (Orthanilamide)

邻氨基苯磺酰胺,Orthanilamide

2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.

GC34178 Isocryptotanshinone

异隐丹参酮

Isocryptotanshinone是一种有效的信号传导与转录激活因子3(STAT3)和蛋白酪氨酸磷酸酶1B(PTP1B)的抑制剂，其对PTP1B的IC50值为56.1μM。

GC34149 IDO-IN-6 (NLG-1486)

NLG-1486

IDO-IN-6 (NLG-1486) (NLG-1486) 是一种吲哚胺 2,3-双加氧酶 (IDO) 抑制剂，提取自专利 WO WO2012142237A1，化合物 1486，IC50 <1 μM.

GC34139 IDO-IN-8 (NLG-1487)

NLG-1487

IDO-IN-8 (NLG-1487) (NLG-1487) 是一种吲哚胺 2,3-双加氧酶 (IDO) 抑制剂，提取自专利 WO WO2012142237A1，化合物 1487，IC50 为 1-10 μM.

GC34137 IDO-IN-5 (NLG-1489)

NLG-1489

IDO-IN-5 (NLG-1489) (NLG-1489) 是一种吲哚胺 2,3-双加氧酶 (IDO) 抑制剂，提取自专利 WO WO2012142237A1，化合物 1489，IC50 为 1-10 μM.

GC34132 Bergamottin (5-Geranoxypsoralen)

佛手柑素,5-Geranoxypsoralen; Bergamotine; Bergaptin

A naturally occurring furanocoumarin with diverse biological activities

GC34070 Brusatol

鸦胆子苦醇; NSC 172924

Brusatol是一种Nrf2抑制剂，由从鸦嘴茅中分离提取。

GC34058 NADPH tetrasodium salt

还原型辅酶Ⅱ四钠

NADPH tetrasodium salt是还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的一种钠盐形式，NADPH是细胞内必需的辅因子，充当电子供体。

GC34057 TBHQ (tert-Butylhydroquinone)

特丁基对苯二酚; tert-Butylhydroquinone

TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。

GC34035 Meglutol (Dicrotalic acid)

3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid

An HMG-CoA reductase inhibitor

GC33963 IDO-IN-12 IDO-IN-12是一个吲哚胺2,3-双加氧酶(IDO)抑制剂，来自专利WO2017181849A1。

GC33909 Bergaptol (5-Hydroxypsoralen)

香柑醇,5-Hydroxypsoralen; 4-Hydroxybergapten

Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.

GC33878 Irsogladine maleate (Dicloguamine maleate)

马来酸伊索拉定; Dicloguamine maleate; MN1695

A gastroprotective agent

GC33870 Veledimex racemate (RG-115932 racemate)

INXN-1001 racemate; RG-115932 racemate

Veledimex消旋体（RG-115932消旋体）（INXN-1001消旋体）是veledimex的消旋体。

GC33862 Pyributicarb (TSH-888)

稗草畏,TSH-888

Pyributicarb (TSH-888) 是一种氨基甲酸酯类除草剂，是 CYP3A4 基因和人孕烷 X 受体 (hPXR) 的有效激活剂。

GC33833 Tetrahydrocurcumin (HZIV 81-2)

四氢姜黄素; HZIV 81-2

A metabolite of curcumin with diverse biological activities

GC33816 Ertiprotafib (PTP 112)

PTP 112

Ertiprotafib (PTP 112) 是 PTP1B，IkB 激酶 β 的抑制剂； (IKK-β) 和双 PPARα；和 PPARβ；激动剂，IC50 为 1.6 μ；M 代表 PTP1B，400 nM 代表 IKK-β；EC50 约为 1 μ；M 代表 PPARα；/PPAR`；

GC33791 Isotanshinone IIA

异丹参酮IIA

IsotanshinoneIIA，一个松香型二萜代谢物，能够抑制蛋白酪氨酸磷酸酶1B(PTP1B)的活性，其IC50值为11.4μM。

GC33780 RG-12525 (NID 525)

NID 525

RG-12525 (NID 525) 是一种特异性、竞争性和口服有效的肽白三烯、LTC4、LTD4 和 LTE4 拮抗剂，抑制 LTC4、LTD4 和 LTE4 诱导的豚鼠实质条收缩，IC50 为 2.6 nM，2.5 nM和 7 nM，分别； RG-12525 (NID 525) 也是一种过氧化物酶体增殖物激活受体 gamma (PPAR-gamma) 激动剂，IC50 约为 60 nM，是 CYP3A4 的有效抑制剂，Ki 值为 0.5 μM。