GlpBio

Aminopeptidase

Aminopeptidase(氨肽酶)

Aminopeptidases are a group of enzymes widely distributed among bacteria, fungi, animals and plants that catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates through hydrolysis of peptide bonds near the N-terminal end of a polypeptide chain.  Most aminopeptidases are assembled by relatively high mass (50kDa) subunits exhibiting multimeric structures, whereas some are monomeric. The majority of aminopeptidases are zinc metalloenzymes and hence inhibited by the transition-state analog bestatin.  Aminopeptidases have been found in many subcellular organelles as well as in cytoplasm and membrane, where they are involved in diverse proteolytic pathways and play an essential role in protein maturation, degradation of non-hormonal and hormonal peptides and possibly determination of protein stability.

Aminopeptidase 相关产品(15)

  • GC10406 structure
    GC10406Tosedostat (CHR2797)
    CAS: 238750-77-1
    纯度: >99.50%

    An aminopeptidase inhibitor

  • GC10171 structure
    GC10171Puromycin aminonucleoside
    CAS: 58-60-6
    纯度: >98.00%

    A glomerular epithelial cell toxin

  • GC11780 structure
    GC11780Bestatin
    CAS: 58970-76-6
    纯度: >99.50% / >98.00%

    Bestatin是氨基肽酶N（APN/CD13）抑制剂，其IC 50 值为14.9±3.4μM。

  • GC15577 structure
    GC15577Bestatin hydrochloride
    CAS: 65391-42-6
    纯度: >99.50% / >99.00%

    Bestatin hydrochloride是氨基肽酶N（APN/CD13）抑制剂，其IC 50 值为14.9±3.4μM。

  • GC16350 structure
    GC16350Actinonin
    CAS: 13434-13-4
    纯度: >99.00%

    Actinonin是一种肽模拟抗生素，能够抑制enkephalin-aminopeptidase、enkephalinase A和 dipeptidylaminopeptidase，IC 50 值分别为0.39μM、5.6μM和1.1μM。

  • GC18471 structure
    GC18471DG-051
    CAS: 929915-58-2
    纯度: >99.50%

    An LTA 4 hydrolase inhibitor

  • GC34613 structure
    GC34613HFI-142
    CAS: 332164-34-8
    纯度: >99.00%

    HFI-142是胰岛素调节性氨基肽酶(IRAP)抑制剂，ki值为2.01μM。

  • GC35499 structure
    GC35499Bestatin trifluoroacetate
    CAS: 223763-80-2

    An aminopeptidase inhibitor

  • GC36733 structure
    GC36733NGR peptide Trifluoroacetate
    纯度: >98.00%

    NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽，NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。

  • GC42777 structure
    GC42777Amastatin (hydrochloride)
    CAS: 100938-10-1
    纯度: >97.00%

    An aminopeptidase inhibitor

  • GC62113 structure
    GC62113Firibastat
    CAS: 648927-86-0
    纯度: >99.00%

    Firibastat (QGC001) 是一种口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A (APA) 抑制剂 (Ki=200 nM)，选择性和特异性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III，并降低血压。

  • GC63435 structure
    GC63435LTA4H-IN-1
    CAS: 1799681-85-8
    纯度: >98.50%

    An inhibitor of LTA 4 hydrolase

  • GC67997 structure
    GC67997Aminopeptidase-IN-1
    CAS: 374102-08-6

    Aminopeptidase-IN-1 (compound 16o) 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂，Ki 为 7.7 μM。Aminopeptidase-IN-1 可用于研究认知和记忆障碍。

  • GC72068 structure
    GC72068Batatasin IV
    CAS: 60347-67-3
    纯度: 不显示

    Batatasin IV是一种具有抗炎活性的LTA4H抑制剂。

  • GC73861 structure
    GC73861HFI-437
    CAS: 1110650-74-2
    纯度: >99.00%

    HFI-437是一种有效的非肽类胰岛素调节氨基肽酶（IRAP）抑制剂，Ki值为20 nM。