GlpBio

PDE

PDE(磷酸二酯酶)

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

PDE 相关产品(241)

  • GC10004 structure
    GC10004Enoximone
    CAS: 77671-31-9
    纯度: >98.00%

    A PDE3 inhibitor

  • GC10077 structure
    GC10077S- (+)-Rolipram
    CAS: 85416-73-5
    纯度: >99.50%

    S- (+)-Rolipram ((+)-Rolipram) 是一种环状 AMP(cAMP) 特异性磷酸二酯酶 4 (PDE4) 抑制剂，IC50 为 1100 nM。

  • GC10109 structure
    GC10109Cilostamide
    CAS: 68550-75-4
    纯度: >98.00%

    A selective inhibitor of PDE3

  • GC10420 structure
    GC10420Apremilast (CC-10004)
    CAS: 608141-41-9
    纯度: >99.50%

    An orally available PDE4 inhibitor

  • GC10542 structure
    GC10542CP 80633
    CAS: 135637-46-6

    Inhibitor of phosphodiesterase type 4

  • GC10588 structure
    GC10588Vardenafil HCl Trihydrate
    CAS: 330808-88-3

    An inhibitor of PDE5 and PDE6

  • GC10648 structure
    GC10648PF-04447943
    CAS: 1082744-20-4
    纯度: >99.50%

    A PDE9A inhibitor

  • GC11072 structure
    GC11072Nortadalafil
    CAS: 171596-36-4
    纯度: >99.50%

    诺他达拉非是去甲基他达拉非，它是一种 PDE5 抑制剂，目前以药丸形式销售，用于治疗勃起功能障碍 (ED)，名称为 Cialis；并以 Adcirca 的名义用于治疗肺动脉高压。

  • GC11273 structure
    GC11273Anagrelide HCl
    CAS: 58579-51-4
    纯度: >99.50%

    A PDE3 inhibitor

  • GC11313 structure
    GC11313ICI 63197
    CAS: 27277-00-5

    A PDE3 and PDE4 inhibitor

  • GC11369 structure
    GC11369Sildenafil
    CAS: 139755-83-2
    纯度: >99.50% / >98.00%

    西地那非，作为一种磷酸二酯酶 5 (PDE-5) 抑制剂，用于治疗肺动脉高压 (PAH)。

  • GC11472 structure
    GC11472AN-2728
    CAS: 906673-24-3

    A selective PDE4 inhibitor

  • GC11684 structure
    GC11684MY-5445
    CAS: 78351-75-4
    纯度: >99.00%

    A PDE5 inhibitor

  • GC11730 structure
    GC11730IBMX
    CAS: 28822-58-4
    纯度: >99.00% / >98.00%

    IBMX 是一种非特异性磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3、PDE4 和 PDE5，IC50 值为 6.5、26.3 和 31.7 µm，但 PDE8A、PDE8B 和 PDE9 除外 。

  • GC11789 structure
    GC11789T 0156 hydrochloride
    CAS: 324572-93-2

    T 0156 hydrochloride 是一种有效的选择性 5 型磷酸二酯酶 (PDE5) 抑制剂。

  • GC12059 structure
    GC12059YM 976
    CAS: 191219-80-4

    A PDE4 inhibitor

  • GC12764 structure
    GC12764Aminophylline
    CAS: 317-34-0
    纯度: >99.50%

    A phosphodiesterase inhibitor and adenosine receptor antagonist

  • GC12771 structure
    GC12771Etazolate hydrochloride
    CAS: 35838-58-5

    PDE-4 inhibitor and selective GABA-A receptor modulator

  • GC12808 structure
    GC12808Pimobendan
    CAS: 74150-27-9
    纯度: >99.00%

    An inhibitor of PDE3

  • GC12878 structure
    GC12878MMPX
    CAS: 78033-08-6

    calmodulin-sensitive cyclic GMP phosphodiesterase inhibitor

  • GC13121 structure
    GC13121Piclamilast
    CAS: 144035-83-6

    A PDE4 inhibitor

  • GC13495 structure
    GC13495Trequinsin hydrochloride
    CAS: 78416-81-6
    纯度: >99.50%

    An inhibitor of PDE3

  • GC13652 structure
    GC13652Dyphylline
    CAS: 479-18-5
    纯度: >99.00%

    An adenosine receptor antagonist and phosphodiesterase inhibitor

  • GC13657 structure
    GC13657Mesopram
    CAS: 189940-24-7

    PDE4 inhibitor, orally active