GlpBio

PDE

PDE(磷酸二酯酶)

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

PDE 相关产品(241)

  • GC13842 structure
    GC13842Ro 20-1724
    CAS: 29925-17-5
    纯度: >98.00% / >95.00%

    Ro 20-1724是一种选择性cAMP特异性磷酸二酯酶（PDE4）抑制剂，IC 50 值为1.930μM。

  • GC14398 structure
    GC14398Siguazodan
    CAS: 115344-47-3
    纯度: >99.00%

    Siguazodan (SKF 94836) 是一种有效的、选择性的、具有口服活性的磷酸二酯酶 III (PDE-III) 抑制剂，IC50 为 117 nM。

  • GC15189 structure
    GC15189Gisadenafil besylate
    CAS: 334827-98-4

    A PDE5 inhibitor

  • GC15194 structure
    GC15194PF-2545920
    CAS: 1292799-56-4

    A potent inhibitor of PDE10A

  • GC15472 structure
    GC15472BRL 50481
    CAS: 433695-36-4
    纯度: >99.50%

    A potent, selective inhibitor of PDE7

  • GC15475 structure
    GC15475RS 25344 hydrochloride
    CAS: 152815-28-6
    纯度: >99.50%

    RS 25344 hydrochloride 是一种选择性 cAMP-磷酸二酯酶 4 (PDE 4; PDE IV) 抑制剂，对人淋巴细胞的 IC50 为 0.28 nM。

  • GC15890 structure
    GC15890Cilostazol
    CAS: 73963-72-1
    纯度: >99.50%

    A PDE3A inhibitor

  • GC16048 structure
    GC16048BC 11-38
    CAS: 686770-80-9
    纯度: >98.00%

    A potent and selective PDE11 inhibitor

  • GC16347 structure
    GC16347Roflumilast
    CAS: 162401-32-3
    纯度: >99.00%

    A PDE4 inhibitor

  • GC16426 structure
    GC16426Zardaverine
    CAS: 101975-10-4
    纯度: >98.50%

    A dual inhibitor of PDE3 and PDE4

  • GC16632 structure
    GC16632CDP 840 hydrochloride
    CAS: 162542-90-7

    CDP 840 hydrochloride (GR259653X) 是一种有效的、选择性的和口服活性的磷酸二酯酶 IV (PDE IV) 抑制剂。

  • GC17074 structure
    GC17074Tadalafil
    CAS: 171596-29-5
    纯度: >99.50%

    Tadalafil是一种有效、可逆且具有选择性的磷酸二酯酶5（PDE5）小分子抑制剂，IC 50 为1.8nM。Tadalafil还能够抑制PDE11（IC 50 为11nM）。

  • GC17221 structure
    GC17221Olprinone Hydrochloride
    CAS: 119615-63-3
    纯度: >99.50%

    An inhibitor of PDE3

  • GC17598 structure
    GC17598Cilomilast
    CAS: 153259-65-5
    纯度: >99.00%

    A PDE4 inhibitor

  • GC17999 structure
    GC17999TC-E 5005
    CAS: 959705-64-7

    PDE10A inhibitor

  • GC10796 structure
    GC10796Eggmanone
    CAS: 505068-32-6

    A selective phosphodiesterase 4 inhibitor

  • GC10859 structure
    GC10859Amino Tadalafil
    CAS: 385769-84-6
    纯度: >99.50%

    An analog of tadalafil

  • GC10869 structure
    GC10869HA-155
    CAS: 1229652-22-5
    纯度: >98.00%

    A selective autotaxin inhibitor

  • GC10944 structure
    GC10944Butein
    CAS: 487-52-5
    纯度: >98.00%

    A plant polyphenol

  • GC11125 structure
    GC11125Sp-Cyclic AMPS (sodium salt)
    CAS: 142439-95-0
    纯度: >98.00%

    A cAMP derivative

  • GC11782 structure
    GC11782Ophiobolin A
    CAS: 4611-05-6
    纯度: >95.00%

    A calmodulin antagonist

  • GC12060 structure
    GC12060Deltarasin hydrochloride
    CAS: 1440898-82-7
    纯度: >99.50%

    A KRAS inhibitor

  • GC12824 structure
    GC12824Dibutyryl-cAMP, sodium salt
    CAS: 16980-89-5
    纯度: >99.50% / >98.00% / >99.00%

    Dibutyryl-cAMP, sodium salt，又称为Bucladesine，是一种细胞膜可透性环核苷酸类似物，能模拟内源性cAMP的作用，并作为磷酸二酯酶抑制剂。

  • GC12909 structure
    GC12909Zaprinast
    CAS: 37762-06-4
    纯度: >98.00%

    Zaprinast是一种磷酸二酯酶抑制剂，主要靶向PDE5和PDE6，IC 50 值分别为0.8μM和0.15μM。