Fatty Acid Synthase (FASN)
Fatty Acid Synthase (FASN)(脂肪酸合成酶)
Fatty Acid Synthase (FASN) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.
Fatty Acid Synthase (FASN) 相关产品(8)
- GC60832FASN-IN-4 tosylateCAS: 2095432-57-6纯度: >98.50%
FASN-IN-4tosylate是高效的脂肪酸合酶FASN抑制剂，来自专利WO2012064642A1化合物实例29，IC50值为10nM。
- GC61896trans-ChalconeCAS: 614-47-1
Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC18496 | Leelamine (hydrochloride) | 16496-99-4 | - | |
An inhibitor of pyruvate dehydrogenase kinase | ||||
| GC25411 | Fasnall | 929978-58-5 | - | |
Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity. | ||||
| GC38967 | Lycorine | 476-28-8 | >98.00% | |
An alkaloid with diverse biological activities | ||||
| GC60832 | FASN-IN-4 tosylate | 2095432-57-6 | >98.50% | |
FASN-IN-4tosylate是高效的脂肪酸合酶FASN抑制剂，来自专利WO2012064642A1化合物实例29，IC50值为10nM。 | ||||
| GC61896 | trans-Chalcone | 614-47-1 | - | |
Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities. | ||||
| GC62571 | IPI-9119 | 1346564-56-4 | >98.00% | |
IPI-9119 is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN), which can inhibit the FASN thioesterase domain by promoting acylation of the catalytic serine with an IC50 of 0.3 nM. | ||||
| GC64974 | FT113 | 1630808-89-7 | >99.00% | |
FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM. | ||||
| GC67894 | FASN-IN-5 | 1309805-49-9 | - | |
FASN-IN-5 (example 11) 是 FASN 抑制剂，可用于研究 TH17 或 CSF1 介导的疾病或障碍，例如癌症、免疫障碍和肥胖症。 | ||||