GlpBio

Factor Xa

Factor Xa(凝血因子 Xa)

Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

Factor Xa 相关产品(59)

  • GC13683 structure
    GC13683Rivaroxaban
    CAS: 366789-02-8
    纯度: >99.50%

    A selective inhibitor of Factor Xa

  • GC15757 structure
    GC15757Ozagrel
    CAS: 82571-53-7
    纯度: >99.50%

    A selective inhibitor of TXA synthase

  • GC17799 structure
    GC17799Betrixaban
    CAS: 330942-05-7
    纯度: >98.00%

    A Factor Xa inhibitor

  • GC11101 structure
    GC111015-R-Rivaroxaban
    CAS: 865479-71-6
    纯度: >99.50%

    5-R-Rivaroxaban 是 Rivaroxaban 的 (R)-对映异构体。

  • GC11644 structure
    GC11644Edoxaban
    CAS: 480449-70-5
    纯度: >98.00%

    Edoxaban (DU-176b) 是一种具有口服活性、高效、选择性和直接的因子 Xa (FXa) 抑制剂，对游离人 FXa 和凝血酶原酶的 Ki 值分别为 0.561 和 2.98 nM。

  • GC12839 structure
    GC12839Edoxaban tosylate monohydrate
    CAS: 1229194-11-9
    纯度: >99.50%

    A potent inhibitor of Factor Xa

  • GC13130 structure
    GC13130Apixaban
    CAS: 503612-47-3
    纯度: >99.50%

    An inhibitor of Factor Xa

  • GC13711 structure
    GC13711Gabexate mesylate
    CAS: 56974-61-9
    纯度: >98.00%

    A serine protease inhibitor

  • GC17726 structure
    GC17726Otamixaban
    CAS: 193153-04-7
    纯度: >98.50%

    Otamixaban(FXV673) 是一种有效的 (Ki = 0.5 nM)、选择性、快速作用、竞争性和可逆的 fXa 抑制剂，可有效抑制游离和凝血酶原结合的 fXa。

  • GC18452 structure
    GC184523,4-Dichloroisocoumarin
    CAS: 51050-59-0
    纯度: >99.50%

    A serine protease inhibitor

  • GC19766 structure
    GC19766Heparin sodium salt (MW 15kDa)
    CAS: 9041-08-1
    纯度: >99.50%

    肝素钠盐（MW 15kDa）（Sodium heparin (MW 15kDa)）是肝素的聚合物，分子量为15kDa。

  • GC19839 structure
    GC19839Trypsin inhibitor(soybean) (≥4000 BAEE Units/mg)
    CAS: 9035-81-8
    纯度: {{1-8}BA-≥4000 BAEE Units/mg / {9}BA-4000 BAEE Units/mg / {10}BA-4120 BAEE Units/mg} / {11}BA-4230BAEE U/mg}

    Trypsin inhibitor(soybean)是一种胰蛋白酶(trypsin)抑制剂，IC 50 为19 µM，也可以抑制胰凝乳蛋白酶，IC 50 为14.3µM。

  • GC25137 structure
    GC25137Betrixaban maleate
    CAS: 936539-80-9

    Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.

  • GC32567 structure
    GC32567RWJ-445167 (3DP-10017)
    CAS: 226566-43-4

    RWJ-445167 (3DP-10017) (3DP-10017) 是凝血酶和因子 Xa 的双重抑制剂，Ki 分别为 4.0 nM 和 230 nM，具有有效的抗血栓形成活性。

  • GC32614 structure
    GC32614BMS-654457
    CAS: 1004551-41-0

    BMS-654457是(FXIa)的小分子可逆抑制剂，与人和兔FXIa结合的Ki值分别为0.2和0.42nM。

  • GC35536 structure
    GC35536BMS-962212
    CAS: 1430114-34-3

    BMS-962212 是直接的，可逆的，选择性 FXIa 抑制剂。 BMS-962212 具有良好的耐受性，快速起效的药效 (PD) 反应和快速消除。 BMS-962212 在活化的部分促凝血酶原激酶时间内依赖性地增加暴露，并且在 FXI 凝血活性中依赖性地降低暴露。

  • GC35962 structure
    GC35962Edoxaban tosylate
    CAS: 480449-71-6
    纯度: >99.00%

    A potent inhibitor of Factor Xa

  • GC36092 structure
    GC36092FXIa-IN-1
    CAS: 1803271-50-2

    FXIa-IN-1 (compound EP-7041) 是一个有效的 β-lactam 共价 heparin-derived factor X XIa (fXIa) 抑制剂。

  • GC36831 structure
    GC36831Ozagrel sodium
    CAS: 189224-26-8
    纯度: >99.50%

    A selective inhibitor of TXA synthase

  • GC40529 structure
    GC405297-hydroxy Warfarin
    CAS: 17834-03-6

    A phase I metabolite of (-)-warfarin

  • GC43696 structure
    GC43696Fondaparinux (sodium salt)
    CAS: 114870-03-0
    纯度: >98.00%

    An inhibitor of Factor Xa

  • GC44966 structure
    GC44966Sucrose octasulfate (potassium salt)
    CAS: 73264-44-5
    纯度: >95.00%

    An alkaline aluminum?sucrose complex

  • GC45620 structure
    GC45620Bromadiolone
    CAS: 28772-56-7
    纯度: 95.00%

    An anticoagulant rodenticide

  • GC46863 structure
    GC46863Apixaban-13C-d3
    CAS: 1261393-15-0
    纯度: >99.00%

    An internal standard for the quantification of apixaban