GlpBio

Factor Xa

Factor Xa(凝血因子 Xa)

Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

Factor Xa 相关产品(59)

  • GC71122 structure
    GC71122GalNAc unconjugated/naked Fitusiran sodium
    纯度: >97.00%

    GalNAc unconjugated/naked Fitusiran sodium，一种没有GalNAc结合的小干扰RNA，特异性靶向抗凝血酶AT信使RNA，以降低肝脏中AT的产生。

  • GC71242 structure
    GC71242ARC19499 sodium
    纯度: >93.00%

    ARC19499 sodium是一种抑制组织因子途径抑制剂(TFPI)的适体，从而使凝块通过外部途径启动和传播。

  • GC71270 structure
    GC71270CH3OCO-D-CHA-Gly-Arg-pNA acetate
    CAS: 80895-10-9
    纯度: >98.50%

    CH3OCO-D-CHA-Gly-Arg-pNA acetate是Xa因子的显色底物。

  • GC71531 structure
    GC71531Ciraparantag acetate
    CAS: 1644388-83-9
    纯度: >98.00%

    Ciraparantag acetate是一种小分子合成的水溶性广谱抗凝剂逆转剂。Ciraparantag通过非共价氢键和电荷相互作用与普通肝素、低分子量肝素、磺达肝癸钠以及直接Xa因子抑制剂和直接凝血酶抑制剂结合，从而中和其抗凝活性并恢复止血功能，且不表现出明显的促凝血作用。

  • GC71580 structure
    GC71580Otamixaban hydrochloride
    CAS: 409081-12-5
    纯度: 不显示

    Otamixaban hydrochloride是一种强效、选择性、速效、竞争性和可逆的fXa抑制剂（Ki=0.5 nM），可有效抑制游离和凝血酶原酶结合的fXa。

  • GC71583 structure
    GC71583Dechloro Rivaroxaban
    CAS: 1415566-28-7
    纯度: >99.00%

    Dechloro Rivaroxaban是一种高度选择性、口服活性的Xa因子抑制剂。

  • GC72438 structure
    GC72438Osocimab
    CAS: 2056878-75-0
    纯度: 95.00%

    Osocimab (BAY 1213790)，抗fxia抗体(Ki=2.4 nM;EC50 = 0.2海里)。

  • GC72527 structure
    GC72527S-(-)-Warfarin
    CAS: 5543-57-7
    纯度: 不显示
  • GC72772 structure
    GC72772Eribaxaban
    CAS: 536748-46-6
    纯度: >98.00%

    Eribaxaban（PD-0348292）是一种口服活性和选择性FXa抑制剂，Ki值为0.32nM。

  • GC73668 structure
    GC73668Frunexian
    CAS: 1803270-60-1
    纯度: >97.00%

    Frunexian (EP-7041)是一种选择性和有效的凝血因子XI/活化因子XI抑制剂，靶向因子XIa。

  • GC74033 structure
    GC74033FXIIa-IN-4
    纯度: >98.00%

    FXIIa-IN-4（化合物22）是一种有效的、选择性的人FXIIa抑制剂，对FXIIa、凝血酶和FXIa的IC50分别为0.032 μM、0.30 μM和bbb50 μM。