GlpBio

Dehydrogenase

Dehydrogenase(脱氢酶)

Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.

Dehydrogenase 相关产品(39)

  • GC10531 structure
    GC10531AGI-5198
    CAS: 1355326-35-0
    纯度: >98.00%

    A potent, selective inhibitor of IDH1 mutations

  • GC13614 structure
    GC13614Mycophenolate Mofetil
    CAS: 128794-94-5
    纯度: >99.50%

    A prodrug form of mycophenolic acid

  • GC14783 structure
    GC14783Trilostane
    CAS: 13647-35-3
    纯度: >99.50%

    A 3β-hydroxysteroid dehydrogenase inhibitor

  • GC17107 structure
    GC17107PluriSIn #1 (NSC 14613)
    CAS: 91396-88-2
    纯度: >99.50%

    A selective inhibitor of stearoyl-CoA desaturase

  • GC17467 structure
    GC17467Gimeracil
    CAS: 103766-25-2
    纯度: >99.50%

    A DYPD inhibitor

  • GC10438 structure
    GC10438WIN 18446
    CAS: 1477-57-2
    纯度: >98.00% / >97.00%

    WIN 18446 (Fertilysin)是乙醛脱氢酶1A2(ALDH1A2)的有效抑制剂，IC 50 值为0.3μM。

  • GC10462 structure
    GC104626-Aminonicotinamide
    CAS: 329-89-5
    纯度: >98.00% / >98.50% / >99.50%

    6-Aminonicotinamide是一种有效的烟酰胺抗代谢物，是竞争性 NADP+ 依赖性酶葡萄糖-6-磷酸脱氢酶 (G6PD) 的抑制剂(K i =0.46μM)。

  • GC10902 structure
    GC10902CVT 10216
    CAS: 1005334-57-5
    纯度: >99.00%

    A selective, reversible ALDH2 inhibitor

  • GC11149 structure
    GC11149L-a-Hydroxyglutaric acid disodium salt
    CAS: 63512-50-5

    An α-hydroxy acid

  • GC12204 structure
    GC12204STK393606
    CAS: 355827-05-3

    A selective inhibitor of 15-PGDH

  • GC13147 structure
    GC13147AG-221 (Enasidenib)
    CAS: 1446502-11-9
    纯度: >99.50%

    An inhibitor of mutant IDH2

  • GC13262 structure
    GC13262A-771726
    CAS: 163451-81-8
    纯度: >98.00%

    An active metabolite of leflunomide

  • GC13336 structure
    GC13336CBR-5884
    CAS: 681159-27-3
    纯度: >99.00%

    A selective PHGDH inhibitor

  • GC13464 structure
    GC13464GSK 2837808A
    CAS: 1445879-21-9
    纯度: >99.00%

    GSK2837808A 是一种选择性的 LDHA (lactate dehydrogenase A) 的抑制剂,对hLDHA和hLDHB的IC50分别为2.6 nM和43 nM.GSK2837808A(10 µM;24-72h)通过促进有氧糖酵解、增殖、细胞周期和细胞凋亡抵抗,阻断了着丝粒蛋白N (CENP-N)过表达对鼻咽癌细胞的影响。

  • GC13611 structure
    GC13611CGP 3466B maleate
    CAS: 200189-97-5
    纯度: >98.00%

    A GAPDH ligand

  • GC13670 structure
    GC13670Methylmalonate
    CAS: 516-05-2
    纯度: >98.00%

    A dicarboxylic acid and byproduct of propionate catabolism

  • GC13760 structure
    GC13760TC HSD 21
    CAS: 330203-01-5

    An inhibitor of 17β-HSD3

  • GC13776 structure
    GC13776Piericidin A
    CAS: 2738-64-9
    纯度: >95.00%

    Piericidin A是一种天然的线粒体NADH-泛醌氧化还原酶（复合物I）抑制剂。

  • GC14757 structure
    GC14757AGI-6780
    CAS: 1432660-47-3
    纯度: >98.00%

    A potent, selective inhibitor of mutant IDH2

  • GC14851 structure
    GC14851Vidofludimus
    CAS: 717824-30-1
    纯度: >98.50%

    An immunosuppressive drug that inhibits DHODH

  • GC14921 structure
    GC14921CPI-613 (Devimistat)
    CAS: 95809-78-2
    纯度: >98.00%

    An inhibitor of α-ketoglutarate dehydrogenase

  • GC15266 structure
    GC15266Qc 1
    CAS: 403718-45-6
    纯度: >98.00%

    Qc 1 是一种可逆的非竞争性苏氨酸脱氢酶 (TDH) 抑制剂。

  • GC15547 structure
    GC15547Inosine-5'-monophosphate (sodium salt hydrate)
    CAS: 20813-76-7

    A 5’-ribonucleoside

  • GC15601 structure
    GC15601AG-120
    CAS: 1448347-49-6
    纯度: >99.50% / >98.00%

    AG-120 (Ivosidenib)是一种突变型异柠檬酸脱氢酶1（mIDH1）抑制剂。