GlpBio

PPAR

PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

PPAR 相关产品(215)

  • GC11152 structure
    GC11152Pioglitazone HCl
    CAS: 112529-15-4
    纯度: >99.50%

    A PPARγ agonist

  • GC11318 structure
    GC11318Rosiglitazone maleate
    CAS: 155141-29-0
    纯度: >99.50%

    A PPARγ agonist

  • GC11423 structure
    GC11423GW1929
    CAS: 196808-24-9
    纯度: >99.50%

    A non-thiazolidinedione activator of PPARγ

  • GC12820 structure
    GC12820T0070907
    CAS: 313516-66-4
    纯度: >99.50%

    T0070907是一种有效的选择性过氧化物酶体增殖物激活受体γ（PPARγ）拮抗剂，IC 50 值为1nM。

  • GC12894 structure
    GC12894Balaglitazone
    CAS: 199113-98-9
    纯度: >99.50%

    A partial agonist of PPARγ

  • GC13204 structure
    GC13204Inolitazone
    CAS: 223132-37-4

    Inolitazone 是一种新型的高亲和力 PPARγ 激动剂，其生物活性依赖于 PPARγ，抑制生长的 IC50 为 0.8 nM。

  • GC13633 structure
    GC13633Ciprofibrate
    CAS: 52214-84-3
    纯度: >99.50%

    A selective PPARα agonist

  • GC13969 structure
    GC13969GW9662
    CAS: 22978-25-2
    纯度: >99.50% / >98.00%

    GW9662是一种特异性的过氧化物酶体增殖物激活受体-γ(PPAR-γ)抑制剂,其IC50为3.3 nM。

  • GC14403 structure
    GC14403WY-14643 (Pirinixic Acid)
    CAS: 50892-23-4
    纯度: >99.50% / >98.00%

    WY-14643 (Pirinixic Acid)是一种高效、具备选择性高亲和力的过氧化物酶体增殖物激活受体α（PPARα）受体激动剂，对小鼠的 PPARα受体的EC 50 为0.63μM，对人的 PPARα受体的EC 50 为5μM。

  • GC14983 structure
    GC14983GW0742
    CAS: 317318-84-6
    纯度: >98.00%

    A selective agonist of PPARδ

  • GC15272 structure
    GC15272Troglitazone
    CAS: 97322-87-7
    纯度: >98.50% / >98.00% / >96.00%

    Troglitazone是一种具有口服活性的过氧化物酶体增殖物激活受体γ（PPARγ）激动剂，对人和鼠的EC 50 值分别为550nM和780nM。

  • GC15318 structure
    GC15318GW501516
    CAS: 317318-70-0
    纯度: >99.00%

    GW501516是一种合成PPARδ特异性激动剂，EC 50 值为0.10nM。

  • GC15516 structure
    GC15516Rosiglitazone HCl
    CAS: 302543-62-0

    A PPARγ agonist

  • GC16009 structure
    GC16009GSK3787
    CAS: 188591-46-0
    纯度: >99.00%

    A selective, irreversible PPARβ/δ antagonist

  • GC16444 structure
    GC16444Rosiglitazone
    CAS: 122320-73-4
    纯度: >99.50% / >98.00%

    Rosiglitazone是一种具有口服活性的过氧化物酶体增殖物活化受体γ（PPARγ ）选择性激动剂，选择性地激活含有PPARγ配体结合域（LBD）的嵌合体，而不是PPARα和PPARδ，EC 50 为60 nM，K d 为40 nM。

  • GC18151 structure
    GC18151Elafibranor (GFT505)
    CAS: 923978-27-2
    纯度: >99.00%

    An agonist of PPARα and PPARδ

  • GC10190 structure
    GC10190DG-172 (hydrochloride)
    CAS: 1361504-77-9
    纯度: >99.00%

    An orally available PPARβ/δ inverse agonist

  • GC10381 structure
    GC10381AUDA
    CAS: 479413-70-2
    纯度: >98.00%

    A potent inhibitor of soluble epoxide hydrolase

  • GC11170 structure
    GC11170Choline Fenofibrate
    CAS: 856676-23-8
    纯度: >98.00%

    非诺贝特胆碱 (ABT-335) 是一种非诺贝酸的胆碱盐，可在胃肠道中释放游离的非诺贝酸。

  • GC11477 structure
    GC11477Darglitazone
    CAS: 141200-24-0
    纯度: >99.00%

    A PPARγ agonist

  • GC11586 structure
    GC11586SR 202
    CAS: 76541-72-5
    纯度: >99.50%

    An antagonist of agonist-induced PPARγ transcriptional activity

  • GC11732 structure
    GC11732GW 590735
    CAS: 622402-22-6;343321-96-0

    A potent and selective agonist of PPARα

  • GC11916 structure
    GC11916GQ-16
    CAS: 870554-67-9

    A PPARγ partial agonist

  • GC12062 structure
    GC12062nTZDpa
    CAS: 118414-59-8

    PPARγ partial agonist