PPAR
PPAR(过氧化物酶体增殖剂激活受体)
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
PPAR 相关产品(215)
- GC39701ConvallatoxinCAS: 508-75-8纯度: >98.00%
Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物，并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂，具有很高的效力和功效。具有抗炎和抗增殖特性。
- GC4110215-deoxy-δ12,14-Prostaglandin D2CAS: 85235-11-6纯度: >95.00%
A metabolite of PGD 2 and an agonist of DP 2
- GC415304-oxo Docosahexaenoic AcidCAS: 845673-74-7纯度: >90.00%
A putative DHA metabolite and PPARγ agonist
- GC43653trans,trans-Farnesyl pyrophosphate ammonium saltCAS: 116057-57-9纯度: >95.00%
An intermediate in sterol biosynthesis
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC39271 | (±)-Naringenin | 67604-48-2 | >98.50% | |
A citrus- derived flavonoid | ||||
| GC39701 | Convallatoxin | 508-75-8 | >98.00% | |
Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物，并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂，具有很高的效力和功效。具有抗炎和抗增殖特性。 | ||||
| GC40384 | CAY10410 | 596104-94-8 | >98.00% | |
A less electrophilic, isosteric analog of 15-deoxy-D12,14-PGJ 2 | ||||
| GC40440 | (±)8(9)-EET | - | >98.00% | |
A racemic version of a CYP450 metabolite of arachidonic acid | ||||
| GC40558 | Hexanoyl Glycine | 24003-67-6 | >95.00% | |
A urinary biomarker | ||||
| GC40636 | Amorfrutin A | 80489-90-3 | >97.00% | |
An antidiabetic natural product | ||||
| GC40764 | CAY10514 | 868526-38-9 | >98.00% | |
A PPARα and PPARγ dual agonist | ||||
| GC40838 | (±)8(9)-EET methyl ester | - | >98.00% | |
An esterified version of (±)8(9)-EET | ||||
| GC41102 | 15-deoxy-δ12,14-Prostaglandin D2 | 85235-11-6 | >95.00% | |
A metabolite of PGD 2 and an agonist of DP 2 | ||||
| GC41339 | Pioglitazone Ketone | 146062-45-5 | >98.00% | |
An active metabolite of pioglitazone | ||||
| GC41492 | Edaglitazone | 213411-83-7 | >98.00% | |
A PPARγ agonist | ||||
| GC41530 | 4-oxo Docosahexaenoic Acid | 845673-74-7 | >90.00% | |
A putative DHA metabolite and PPARγ agonist | ||||
| GC41867 | 10-Nitrolinoleate | 774603-04-2 | >95.00% | |
A nitrated fatty acid and PPARγ agonist | ||||
| GC41868 | 10-Nitrooleate | 875685-46-4 | >98.00% | |
A novel endogenous lipid signalling molecule | ||||
| GC42649 | 9-Nitrooleate | 875685-44-2 | >98.00% | |
A novel endogenous lipid signalling molecule | ||||
| GC42651 | 9-oxo-10(E),12(E)-Octadecadienoic Acid | 54232-58-5 | >90.00% | |
A natural agonist of PPARα | ||||
| GC42791 | Amorfrutin B | 78916-42-4 | >97.00% | |
A PPARγ agonist | ||||
| GC42890 | Azelaoyl PAF | 354583-69-0 | >98.00% | |
A potent PPARγ agonist | ||||
| GC43162 | CAY10506 | 292615-75-9 | >98.00% | |
A PPARγ agonist | ||||
| GC43174 | CAY10573 | 853652-40-1 | >98.00% | |
A PPAR pan-agonist | ||||
| GC43180 | CAY10592 | 685139-10-0 | >98.00% | |
A selective partial PPARδ agonist | ||||
| GC43653 | trans,trans-Farnesyl pyrophosphate ammonium salt | 116057-57-9 | >95.00% | |
An intermediate in sterol biosynthesis | ||||
| GC43723 | Galactosylsphingosine (d18:1) | 2238-90-6 | >95.00% | |
A bioactive sphingolipid | ||||
| GC43743 | Gemfibrozil 1-O-β-Glucuronide | 91683-38-4 | >99.5% | |
A major metabolite of gemfibrozil | ||||