GlpBio

PPAR

PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

PPAR 相关产品(215)

  • GC91136 structure
    GC91136XY-4
    CAS: 474329-47-0
    纯度: >95.00%

    PPARγ的激动剂

  • GC91298 structure
    GC91298(±)-Linalool-d3
    CAS: 1216673-02-7
    纯度: >99.00%

    一种用于量化(±)-芳樟醇的内部标准。

  • GC91933 structure
    GC91933E17241
    CAS: 1060968-92-4
    纯度: >95.00%

    E17241是编码ATP结合盒转运蛋白1的基因ABCA1表达的诱导剂；亚家族A（ABCA1）。

  • GC92033 structure
    GC92033HPG1860
    CAS: 2226133-29-3
    纯度: >98.00%

    HPG1860是一种farnesoid X受体（FXR）激动剂。

  • GC92088 structure
    GC92088GLP-1 (28-36) amide (trifluoroacetate salt)
    纯度: >98.00%

    胰高血糖素样肽1GLP-1 (28-36) amide (trifluoroacetate salt)是内源性GLP-1R激动剂GLP-1（7-36）酰胺的肽和活性代谢产物。

  • GC92131 structure
    GC92131NN1177 (trifluoroacetate salt)
    纯度: >98.00%

    NN1177 (trifluoroacetate salt)是胰高血糖素受体（GCGR）和胰高血糖激素样肽1受体（GLP-1R）的双肽激动剂。

  • GN10030 structure
    GN10030Fisetin
    CAS: 528-48-3
    纯度: >98.50% / >98.00%

    Fisetin是一种天然黄酮醇，存在于许多水果和蔬菜中，具有多种生物活性。

  • GN10098 structure
    GN10098Glabridin
    CAS: 59870-68-7
    纯度: >97.00%

    A natural isoflavonoid with diverse actions

  • GN10276 structure
    GN10276Naringenin
    CAS: 480-41-1
    纯度: >98.50%

    Naringenin是一种柑橘类黄酮化合物，能够用于治疗癌症，具有抗氧化和抗炎活性。

  • GN10278 structure
    GN10278Icariin
    CAS: 489-32-7
    纯度: >98.00%

    淫羊藿甙是一种黄酮醇糖苷。淫羊藿甙抑制PDE5和PDE4活性的IC 50 分别为432 nM和73.50 μM。

  • GN10293 structure
    GN10293Daidzein
    CAS: 486-66-8
    纯度: >99.50%

    An isoflavone

  • GN10301 structure
    GN10301Magnolol
    CAS: 528-43-8
    纯度: >99.50%

    A CB 2 receptor agonist

  • GN10413 structure
    GN10413Agrimol B
    CAS: 55576-66-4
    纯度: >99.50%

    A polyphenol with adipogenesis inhibitory and anticancer activities

  • GN10457 structure
    GN10457Oleuropein
    CAS: 32619-42-4
    纯度: >98.00%

    Oleuropein是橄榄树中的主要酚类化合物，具有强效的抗氧化和抗炎特性。

  • GN10511 structure
    GN10511Eupatilin
    CAS: 22368-21-4
    纯度: >99.00% / >98.00%

    Eupatilin是一种具有多种生物活性的天然黄酮类化合物，是过氧化物酶体增殖物激活受体α（PPARα）的激动剂，具有抗凋亡，抗氧化，及抗炎等功效。

  • GN10538 structure
    GN10538Ginsenoside Rh1
    CAS: 63223-86-9
    纯度: >98.00%

    A steroid glycoside with diverse biological activities

  • GN10678 structure
    GN10678Cinnamyl alcohol
    CAS: 104-54-1
    纯度: >98.00%

    肉桂醇是板栗花的活性成分，抑制 PPARγ 表达增加，具有抗肥胖活性。

  • GN10756 structure
    GN10756Ophiopogonin D
    CAS: 945619-74-9
    纯度: >98.00%

    A steroid glycoside with diverse biological activities

  • GN10762 structure
    GN10762Gypenoside XLIX
    CAS: 94987-08-3
    纯度: >99.00%

    Gypenoside XLIX 是一种达玛烷型糖苷，是 G.

  • GC14948 structure
    GC14948Pioglitazone
    CAS: 111025-46-8
    纯度: >99.50%

    Pioglitazone属于格列酮类或噻唑烷二酮类,是一系列口服降糖药。

  • GC12250 structure
    GC12250Fenofibrate
    CAS: 49562-28-9
    纯度: >99.50% / >99.00% / >97.00%

    A PPARα agonist

  • GC14915 structure
    GC14915Gemfibrozil
    CAS: 25812-30-0
    纯度: >99.50%

    A PPARα and PPARγ agonist

  • GC17377 structure
    GC17377Clofibrate
    CAS: 637-07-0
    纯度: >99.50% / >98.00%

    A selective PPARα agonist